(S,R,S)-AHPC-amido-C5-acid

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(S,R,S)-AHPC-amido-C5-acid manufacturers
(S,R,S)-AHPC-amido-C5-acid Basic information
Product Name:(S,R,S)-AHPC-amido-C5-acid
Synonyms:(S,R,S)-AHPC-amido-C5-acid;7-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptanoic acid;L-Prolinamide, N-(6-carboxy-1-oxohexyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;7-[[(S)-1-[(2S,4R)-4-Hydroxy-2-[[4-(4-methyl-5-thiazolyl)benzyl]carbamoyl]-1-pyrrolidinyl]-3,3-dimethyl-1-oxo-2-butyl]amino]-7-oxoheptanoic Acid;(S,R,S)-AHPC-CO-C5-acid, (S,R,S)-AHPC-amido-C5-acid, 6-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}hexanoic acid, L-Prolinamide, N-(6-carboxy-1-oxohexyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl],methyl]-, (4R)-;VH032-C4-COOH;6-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}hexanoic acid;VH 032 amide-alkyl C5-acid
CAS:2162120-87-6
MF:C29H40N4O6S
MW:572.72
EINECS:
Product Categories:
Mol File:2162120-87-6.mol
(S,R,S)-AHPC-amido-C5-acid Structure
(S,R,S)-AHPC-amido-C5-acid Chemical Properties
Boiling point 881.3±65.0 °C(Predicted)
density 1.257±0.06 g/cm3(Predicted)
storage temp. 2-8°C
form Solid
pka4.75±0.10(Predicted)
color White to yellow
InChIKeyLYAMSRXTXVKKIC-TVZXLZGTSA-N
SMILESC([C@@H](NC(CCCCCC(O)=O)=O)C(C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
(S,R,S)-AHPC-amido-C5-acid Usage And Synthesis
Uses(S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133 (HY-129180)[1].
Biological Activity(S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133 [1].
IC 50VHL
storageStore at -20°C
References[1]. Jian Jin, et al. Compositions and methods for treating cdk4/6-mediated cancer. WO2018106870A1.
(S,R,S)-AHPC-amido-C5-acid Preparation Products And Raw materials
Tag:(S,R,S)-AHPC-amido-C5-acid(2162120-87-6) Related Product Information
rac-8-(((R)-1-((2R,4S)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-8-oxooctanoic acid 6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid VH032-C5-COOH L-Prolinamide, N-(4-carboxy-1-oxobutyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- VH 032 amide-alkylC2-acid (S,R,S)-Ahpc-C6-NH2