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Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)-

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Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- manufacturers
Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- Basic information
Product Name:Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)-
Synonyms:Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)-;EAAT2 activator 1;3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine;F2005-0304;GLT-1,Excitatory amino acid transporter 2,inhibit,Glutamate transporter 1,Inhibitor,EAAT-2 activator 1,EAAT2 activator 1,EAAT2,glutamate transporter,synapse;ω- transaminase;EAAT2 activator 1, 10 mM in DMSO
CAS:892415-28-0
MF:C16H11ClFN3S
MW:331.8
EINECS:
Product Categories:
Mol File:892415-28-0.mol
Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- Structure
Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- Chemical Properties
Boiling point 527.6±50.0 °C(Predicted)
density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 25 mg/mL (75.35 mM; ultrasonic and warming and heat to 60°C)
pka0.65±0.19(Predicted)
form Solid
color Light brown to brown
Safety Information
MSDS Information
Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- Usage And Synthesis
UsesEAAT2 activator 1 is the potent activator of excitatory amino acid transporter 2 (EAAT2). EAAT2 is the major glutamate transporter and functions to remove glutamate from synapses. EAAT2 activator 1 increases EAAT2 protein levels dose-dependently[1].
Biological ActivityEAAT2 activator 1 is the potent activator of excitatory amino acid transporter 2 (EAAT2). EAAT2 is the major glutamate transporter and functions to remove glutamate from synapses. EAAT2 activator 1 increases EAAT2 protein levels dose-dependently[1].
IC 50EAAT2
References[1]. Xing X, et al. Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg Med Chem Lett. 2011;21(19):5774-5777.
Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- Preparation Products And Raw materials
Tag:Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)-(892415-28-0) Related Product Information
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