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5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI)

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5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI) Suppliers list
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Products Intro: Product Name:5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI)
CAS:604769-01-9
Purity:99% Package:1KG;7USD
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:R306465
CAS:604769-01-9
Purity:99.64% Package:1mg;139USD|5mg;352USD|10mg;620USD Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:R306465
CAS:604769-01-9
Purity:98% Package:5mg Remarks:V5627
Company Name: ShenZhen Trendseen Biological Technology Co.,Ltd.
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Products Intro: Product Name:R306465(JNJ-16241199)
CAS:604769-01-9
Purity:99% Package:1kg；25kg
Company Name: Jilin Chinese Academy of Sciences-yanshen Technology
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Products Intro: Product Name:N-Hydroxy-2-(4-(naphthalen-2-ylsulfonyl)piperazin-1-yl)pyrimidine-5-carboxamide
CAS:604769-01-9
Purity:95%+ Package:1g;5g;10g;25g;50g;100g; Remarks:accept Custom Synthesis Services, support large packing

5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI) manufacturers

  • R306465
  • R306465 pictures
  • $113.00 / 1mg
  • 2026-03-13
  • CAS:604769-01-9
  • Min. Order:
  • Purity: 98.46%
  • Supply Ability: 10g
5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI) Basic information
Product Name:5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI)
Synonyms:5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI);5-PyriMidinecarboxaMide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]-;JNJ 16241199;N-Hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]-5-pyrimidinecarboxamide;R 306465;N-hydroxy-2-[4-(naphthalen-2-ylsulfonyl)piperazin-1-yl]pyriMidine-5-carboxaMide;R306465(JNJ-16241199);JNJ-16241199; JNJ16241199; JNJ 16241199
CAS:604769-01-9
MF:C19H19N5O4S
MW:413.45
EINECS:
Product Categories:
Mol File:604769-01-9.mol
5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI) Structure
5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI) Chemical Properties
density 1.466
storage temp. Store at 0-8 °C
form Solid
pka8.10±0.10(Predicted)
color White to off-white
Safety Information
MSDS Information
5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI) Usage And Synthesis
UsesJNJ-16241199 (R306465) is an orally active, selectivehydroxamate-based histone deacetylase (HDAC) inhibitor, with theIC50of 3.3 nM and 23 nM for HDAC1and HDAC8, respectively.JNJ-16241199induces histone 3 acetylation and strongly increases the expression of p21waf1, cip1 in A2780 ovarian carcinoma cells.JNJ-16241199 inducescell apoptosisand shows anticancer activityin a broad spectrum of human malignancies. JNJ-16241199 can be used for cancer study[1].
in vivo

JNJ-16241199 (R306465) inhibits proliferation in acute lymphoblastic leukaemia (ALL), AML, chronic lymphoblastic leukaemia (CLL), chronic myeloid leukaemia (CML), lymphoma and myeloma tumour cells (IC50 values = 15–486 nM) [1].
JNJ-16241199 inhibits the primary human mammary epithelial cell (HMEC) proliferation with the IC50 of 32 nM, and is insensitive to quiescent, non-proliferative HMEC cells (IC50 = 7815 nM) [1].
JNJ-16241199 (0.1, 0.3, 1 μM, 24-48 h) induces apoptosis and inhibits angiogenesis in A2780 cell line[1].

Animal Model:Human A2780, H460 and HCT116 orthotopic xenograft tumor models[1]
Dosage:10-40 mpk/day for 28 days
Administration:Oral gavage (p.o.)
Result:Induced H3 acetylation and p21waf1, cip1 promoter activity in A2780 ovarian tumour tissue.
Decreased tumour volume in three orthotopic xenograft tumor models.
Reached maximal decrease in final tumour volume to 76–87% in human A2780 orthotopic xenograft tumor models.
IC 50HDAC1: 3.3 nM (IC50); HDAC8: 23 nM (IC50)
References[1] Arts J, et al. R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies. Br J Cancer. 2007;97(10):1344-1353. DOI:10.1038/sj.bjc.6604025
5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI) Preparation Products And Raw materials
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