| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Company Name: |
Sigma-Aldrich |
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
Methiothepin mesylate serotinin 5-HT(1) ant manufacturers
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| | Methiothepin mesylate serotinin 5-HT(1) ant Basic information |
| Product Name: | Methiothepin mesylate serotinin 5-HT(1) ant | | Synonyms: | 1-[10,11-dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine mesylate salt;Metitepine mesylate salt, 1-[10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine mesylate salt;Metitepine mesylate salt;Ro 8-6837 mesylate;Methiothepin mesylate 1-Methyl-4-(3-methylsulfanyl-5,6-
dihydrobenzo[b][1]benzothiepin-5-yl)piperazine;1-Methyl-4-(8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl)piperazine methanesulfonate;Ro 8-6837,inhibit,Methiothepin mesylate,Serotonin Receptor,Metitepine,Methiothepin,5-HT Receptor,5-hydroxytryptamine Receptor,Inhibitor;Methiothepin mesylate, 10 mM in DMSO | | CAS: | 74611-28-2 | | MF: | C20H24N2S2CH3SO3H | | MW: | 0 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 74611-28-2.mol |  |
| | Methiothepin mesylate serotinin 5-HT(1) ant Chemical Properties |
| storage temp. | Store at -20°C | | solubility | H2O: soluble13mg/mL | | form | solid | | color | white | | Water Solubility | H2O: 13mg/mL | | InChI | 1S/C20H24N2S2.CH4O3S/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;1-5(2,3)4/h3-8,14,18H,9-13H2,1-2H3;1H3,(H,2,3,4) | | InChIKey | CZMDZGZYKOGLJY-UHFFFAOYSA-N | | SMILES | CS(O)(=O)=O.CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1 |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | Methiothepin mesylate serotinin 5-HT(1) ant Usage And Synthesis |
| Uses | Methiothepin mesylate salt has been used to explore the relationship between circulating cells and the niche. It has also been used in serotonin (5-HT) and antagonists in vivo bioassays and in in vivo antagonist and lipopolysaccharide stimulations. | | General Description | Methiothepin belongs to a new class of dibenzothiophenes. Methiothepin possesses neuroleptic activity. | | Biochem/physiol Actions | Methiothepin mesylate salt is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors. | | IC 50 | 5-HT1A Receptor: 7.10 (pKd); 5-HT1B Receptor: 7.28 (pKd); 5-HT1C Receptor: 7.56 (pKd); 5-HT1D Receptor: 6.99 (pKd); 5-HT5A Receptor: 7.0 (pKd); 5-HT5B Receptor: 7.8 (pKd); 5-HT6 Receptor: 8.74 (pKd); 5-HT7 Receptor: 8.99 (pKd); 5-HT2A Receptor: 8.50 (pKi); 5-HT2B Receptor: 8.68 (pKi); 5-HT2C Receptor: 8.35 (pKi) |
| | Methiothepin mesylate serotinin 5-HT(1) ant Preparation Products And Raw materials |
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