Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)-

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Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)- Suppliers list
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Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)- Basic information
Product Name:Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)-
Synonyms:Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)-;SR10221;(S)-2-(5-((5-(((S)-1-(4-(tert-Butyl)phenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-2-chlorophenoxy)propanoic acid
CAS:1415321-64-0
MF:C33H37ClN2O4
MW:561.11
EINECS:
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Mol File:1415321-64-0.mol
Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)- Structure
Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)- Chemical Properties
Boiling point 773.7±60.0 °C(Predicted)
density 1.19±0.1 g/cm3(Predicted)
solubility DMSO: Soluble: =10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml
pka3.11±0.10(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)- Usage And Synthesis
DescriptionSR10221 is a PPARγ inverse-agonist. SR10221 represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines.
UsesSR10221, a noncovalent inverse agonist of PPARγ, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines[1].
References[1] Sean Irwin, et al. Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists. J Biol Chem. 2022 Nov;298(11):102539. DOI:10.1016/j.jbc.2022.102539
Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)- Preparation Products And Raw materials
Tag:Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)-(1415321-64-0) Related Product Information
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