|
|
| | Benzonitrile, 3-amino-5-methoxy- (9CI) Basic information |
| | Benzonitrile, 3-amino-5-methoxy- (9CI) Chemical Properties |
| Melting point | 81-85 °C | | Boiling point | 322.6±27.0 °C(Predicted) | | density | 1.17±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 2.37±0.10(Predicted) | | Appearance | Light yellow to brown Solid |
| | Benzonitrile, 3-amino-5-methoxy- (9CI) Usage And Synthesis |
| Synthesis | In a three-necked flask, 3-methoxy-5-nitrobenzonitrile (8.0 g, 0.045 mol) was dissolved in methanol (80 mL), 10% palladium-carbon catalyst (1.4 g) and ammonium acetate (6.9 g, 0.090 mol) were added. Hydrogen was introduced and the reaction was stirred at 40 °C for 8 hours. After completion of the reaction, filtration was carried out and the filter cake was washed with methanol (15 mL x 3). The filtrates were combined and concentrated under reduced pressure. The concentrate was poured into 50 mL of water and extracted with ethyl acetate (40 mL x 3). The organic phases were combined, dried with anhydrous sodium sulfate, and the solvent was removed by evaporation under reduced pressure to give 3-amino-5-methoxybenzonitrile as a solid 6.5 g in 98.2% yield. | | References | [1] Patent: CN107573264, 2018, A. Location in patent: Paragraph 0023-0025; 0040-0042; 0057-0059; 0074-0076 |
| | Benzonitrile, 3-amino-5-methoxy- (9CI) Preparation Products And Raw materials |
|