- Quinupristin
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- $98.00
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2026-05-11
- CAS:120138-50-3
- Purity: 98.05%
- Supply Ability: 10g
- Quinupristin
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- $107.00
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2025-05-09
- CAS:120138-50-3
- Purity: 98.16%
- Supply Ability: 10g
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| | Quinupristin Basic information |
| | Quinupristin Chemical Properties |
| Melting point | ~200° | | density | 1.388±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | DMF: Soluble
DMSO: Soluble
Ethanol: Soluble
Methanol: Soluble | | pka | 3.519±0.35(predicted) | | form | Solid | | color | White to off-white | | Henry's Law Constant | 4.9×1022 mol/(m3Pa) at 25℃, HSDB (2015) |
| | Quinupristin Usage And Synthesis |
| Description | Quinupristin is a streptogramin antibiotic that blocks peptide bond formation and peptide extension in bacteria. Quinupristin is usually combined with another streptogramin antibiotic, dalfopristin , to produce quinupristin-dalfopristin complex , known commercially as Synercid. While both quinupristin and dalfopristin have bacteriostatic effects, they act synergistically to kill Gram-positive bacteria, as well as some Gram-negative and anaerobic bacteria. | | Chemical Properties | White to off-white solid, soluble in ethanol, methanol, DMSO and water, unstable in aqueous solution. | | Uses | Semisynthetic depsipeptide type I streptogramin. An antibacterial agent. | | Uses | Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogyrcin B, pristinamycin IA, streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of quinucidinylthiol to the methylene group affords quinupristin. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Quinupristin is used commercially in synergistic combination with dalfopristin (30:70). There is little published data on the synthesis, biological or antibiotic activity of quinupristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains. | | Uses | Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogrycin B, pristinamycin IA, streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of quinucidinylthiol to the methylene group affords quinupristin. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Quinupristin is used commercially in synergistic combination with dalfopristin (30:70). There is little published data on the synthesis, biological or antibiotic activity of quinupristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains. | | References | [1] MICHAEL A. KOHANSKI James J C Daniel J Dwyer. How antibiotics kill bacteria: from targets to networks[J]. Nature Reviews Microbiology, 2010, 8 6: 423-435. DOI: 10.1038/nrmicro2333
[2] JONAS NOESKE. Synergy of streptogramin antibiotics occurs independently of their effects on translation.[J]. Antimicrobial Agents and Chemotherapy, 2014: 5269-5279. DOI: 10.1128/aac.03389-14
[3] WILSON D N. The A-Z of bacterial translation inhibitors.[J]. Critical Reviews in Biochemistry and Molecular Biology, 2009, 44 6: 393-433. DOI: 10.3109/10409230903307311 |
| | Quinupristin Preparation Products And Raw materials |
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