| Company Name: |
Artis Biotech Co. Ltd.
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sales@artisbio.com |
| Products Intro: |
Product Name:Ambruticin
CAS:58857-02-6
Purity:98% HPLC Package:1mg;5mg;10mg;50mg
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| Company Name: |
Changsha Fuzhen Biotechnology Co.，LTD
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| Tel: |
15111215862 18229892877 |
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3062105966@qq.com |
| Products Intro: |
Product Name:Ambruticin
CAS:58857-02-6
Purity:95% Package:100mg;1g;5g
|
| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
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marketing@targetmol.cn |
| Products Intro: |
Product Name:Ambruticin
CAS:58857-02-6
Package:5mg
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| | Ambruticin Basic information |
| Product Name: | Ambruticin | | Synonyms: | Ambruticin;(+)-ambruticin S;L-gluco-Non-8-enonic acid, 3,7-anhydro-2,4,8,9-tetradeoxy-9-[(1S,2S,3R)-2-[(1E,3R,4E)-5-[(2R,6R)-6-ethyl-3,6-dihydro-5-methyl-2H-pyran-2-yl]-3-methyl-1,4-hexadien-1-yl]-3-methylcyclopropyl]-, (8E)-;W 7783;W7783;W-7783 | | CAS: | 58857-02-6 | | MF: | C28H42O6 | | MW: | 474.634 | | EINECS: | | | Product Categories: | | | Mol File: | 58857-02-6.mol |  |
| | Ambruticin Chemical Properties |
| Toxicity | LD50 intravenous in mouse: 315mg/kg |
| | Ambruticin Usage And Synthesis |
| Originator | Ambruticin,Universitet
Karlsruhe (TH) | | Uses | Antifungal. | | Therapeutic Function | Antifungal | | in vivo | The acute LD50 values for the sodium salt of Ambruticin in mice were: intravenous 315 mg/kg, oral > 1000 mg/kg[1].
Ambruticin is rapidly absorbed by the oral route in mice. Ambruticin (75 mg/kg, gavage) produces a peak serum level of 46 μg/mL with a serum half-life of 3.1 h[2].
Ambruticin (40 mg/kg, oral, twice daily for a total of 10 days) shows protective activity in Guinea pigs infected with a severe T. mentagrophytes challenge[2].
Ambruticin shows protective activity in mice acutely infected with a severe C. albicans challenge[2].
| Animal Model: | Guinea pigs (infected with a strain of T. mentagrophytes)[2] | | Dosage: | 40 mg/kg | | Administration: | Oral, starting on day 3 postinfection, twice daily for a total of 10 days | | Result: | On postinfection day 15, the guinea pig mean lesion score was approximately 1.3; by postinfection day 27, all the lesions were essentially healed. |
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| | Ambruticin Preparation Products And Raw materials |
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