Boronic acid, B-[1-[5,6,7,8-tetrahydro-7-(8-methyl-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-4-piperidinyl]-

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Boronic acid, B-[1-[5,6,7,8-tetrahydro-7-(8-methyl-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-4-piperidinyl]- Basic information
Product Name:Boronic acid, B-[1-[5,6,7,8-tetrahydro-7-(8-methyl-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-4-piperidinyl]-
Synonyms:KRAS G12D inhibitor 11;Boronic acid, B-[1-[5,6,7,8-tetrahydro-7-(8-methyl-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-4-piperidinyl]-
CAS:2648551-72-6
MF:C29H38BN5O3
MW:515.46
EINECS:
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Mol File:2648551-72-6.mol
Boronic acid, B-[1-[5,6,7,8-tetrahydro-7-(8-methyl-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-4-piperidinyl]- Structure
Boronic acid, B-[1-[5,6,7,8-tetrahydro-7-(8-methyl-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-4-piperidinyl]- Chemical Properties
Boiling point 772.5±70.0 °C(Predicted)
density 1.29±0.1 g/cm3(Predicted)
pka10.15±0.20(Predicted)
Safety Information
MSDS Information
Boronic acid, B-[1-[5,6,7,8-tetrahydro-7-(8-methyl-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-4-piperidinyl]- Usage And Synthesis
UsesKRAS G12D inhibitor 11 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 11 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021108683A1, compound 52)[1].
References[1] Jennifer PITZEN, et al. Covalent ras inhibitors and uses thereof. Patent WO2021108683A1.
Boronic acid, B-[1-[5,6,7,8-tetrahydro-7-(8-methyl-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-4-piperidinyl]- Preparation Products And Raw materials
Tag:Boronic acid, B-[1-[5,6,7,8-tetrahydro-7-(8-methyl-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-4-piperidinyl]-(2648551-72-6) Related Product Information
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