NQ301
| 中文名称 | NQ301 |
|---|---|
| 中文同义词 | 化合物NQ301;NQ301游离态;NQ 301,CD45抑制剂;2-((4-乙酰基苯基)氨基)-3-氯萘-1,4-二酮;化合物NQ301,10 MM DMSO 溶液;NQ301 ,S0141;NQ301 (NQ-301;CD45 inhibitor 211;Compound 211);2-[(4-乙酰基苯基)氨基] -3-氯-1,4-萘二酮 |
| 英文名称 | NQ301 |
| 英文同义词 | NQ301;NQ301 - Compound 211;NQ 301; NQ-301;2-((4-acetylphenyl)amino)-3-chloronaphthalene-1,4-dione;2-(4-Acetylanilino)-3-chloronaphthalene-1,4-dione;2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione;1,4-Naphthalenedione, 2-[(4-acetylphenyl)amino]-3-chloro-;NQ301 >=98% (HPLC) |
| CAS号 | 130089-98-4 |
| 分子式 | C18H12ClNO3 |
| 分子量 | 325.75 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 130089-98-4.mol |
| 结构式 |  |
NQ301 性质
| 熔点 | 241-243 °C(Solv: ethanol (64-17-5)) |
|---|---|
| 沸点 | 476.8±45.0 °C(Predicted) |
| 密度 | 1.40±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO:10.0(最大浓度 mg/mL);30.7(最大浓度 mM) |
| 形态 | 粉末 |
| 酸度系数(pKa) | -5.25±0.20(Predicted) |
| 颜色 | 淡红色至深红色 |
| InChI | 1S/C18H12ClNO3/c1-10(21)11-6-8-12(9-7-11)20-16-15(19)17(22)13-4-2-3-5-14(13)18(16)23/h2-9,20H,1H3 |
| InChIKey | LSQZKIQSQHZVQS-UHFFFAOYSA-N |
| SMILES | O=C1C(Cl)=C(NC2=CC=C(C(C)=O)C=C2)C(C3=CC=CC=C31)=O |
| Target | Value |
|
TXA2 receptor
() | |
|
CD45
(Cell-free assay) | 200 nM |
NQ301 concentration-dependently inhibits collagen (10 mg/mL)-, U46619 (1 mg/mL)- and arachidonic acid (100 mg/mL)-challenged rabbit platelet aggregation, with IC 50 values of 0.60±0.02, 0.58±0.04 and 0.78±0.04 μM, respectively. NQ301 potently suppresses thromboxane B 2 formation by platelets that are exposed to arachidonic acid in a concentration-dependent manner, but had no effect on the production of prostaglandin D 2 , indicating an inhibitory effect on thromboxane A 2 synthase. NQ301 has a potential to inhibit thromboxane A 2 synthase activity with thromboxane A 2 /prostaglandin H 2 receptor blockade, and modulate arachidonic acid liberation as well as 12-hydroxy-5,8,10,14-eicosatetraenoic acid formation in platelets. NQ301 inhibits platelet aggregation by suppression of the intracellular pathway, rather than by direct inhibition of fibrinogen-GPIIb/IIIa complex binding. NQ301 significantly inhibits the increase of cytosolic Ca 2+ concentration and ATP secretion, and also significantly increases platelet cAMP levels in the activated platelets. The antiplatelet activity of NQ301 may be mediated by inhibition of cytosolic Ca 2+ mobilization, enhancement of cAMP production and inhibition of ATP secretion in activated platelets.
安全信息
| 危险品运输编号 | UN 3077 9 / PGIII |
|---|---|
| WGK Germany | WGK 3 |
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 危害水生环境-急性危害 类别1 眼部刺激 类别2 经皮刺激 类别2 特异性靶器官毒性-一次接触，类别3 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/07/06 | S0141 | NQ301 NQ301 | 130089-98-4 | 5mg | 668.78元 |
| 2026/07/06 | S0141 | NQ301 NQ301 | 130089-98-4 | 25mg | 1577.61元 |