AZD4747

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Company Name: Daicel Chiral Technologies (China)CO.,LTD  
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AZD4747 manufacturers

  • AZD4747
  • AZD4747 pictures
  • $137.00
  • 2026-08-15
  • CAS:2489226-14-2
  • Purity: 99.36%
  • Supply Ability: 10g
AZD4747 Basic information
Product Name:AZD4747
Synonyms:AZD4747;1-((R)-9-((S)-2-Chloro-6-hydroxyphenyl)-10-fluoro-8-(prop-1-yn-1-yl)-3,4,12,12a-tetrahydro-6H-benzo[f]pyrazino[2,1-c][1,4]oxazepin-2(1H)-yl)prop-2-en-1-one;2-Propen-1-one, 1-[(9aS,12aR)-9-(2-chloro-6-hydroxyphenyl)-10-fluoro-3,4,12,12a-tetrahydro-8-(1-propyn-1-yl)-6H-pyrazino[2,1-c][1,4]benzoxazepin-2(1H)-yl]-;1-[(9aS,12aR)-9-(2-Chloro-6-hydroxyphenyl)-10-fluoro-3,4,12,12a-tetrahydro-8-(1-propyn-1-yl)-6H-pyrazino[2,1-c][1,4]benzoxazepin-2(1H)-yl]-2-propen-1-one;ABC-259266
CAS:2489226-14-2
MF:C24H22ClFN2O3
MW:440.9
EINECS:
Product Categories:
Mol File:2489226-14-2.mol
AZD4747 Structure
AZD4747 Chemical Properties
Boiling point 612.703±55.00 °C(Press: 760.00 Torr)(predicted)
density 1.404±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka7.898±0.40(predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
AZD4747 Usage And Synthesis
UsesAZD4747 is a selective, blood-brain barrier-permeable mutant GTPase KRASG12C inhibitor. AZD4747 has the potential to study cancer[1].
in vivo

AZD4747 (1.1-2.3 μM/kg (i.v.); 2.3-6.8 μM/kg (p.o.); single) shows clearances of moderate to high, with 52 and 75% of hepatic blood flow for the mouse and rat, respectively[1].

Animal Model:Male CD1 mice, male Wistar Han rats[1].
Dosage: Mouse: 2.3 μM/kg (i.v.); 6.8 μM/kg (p.o.);
Rat: 1.1-2.3 μM/kg (i.v.); 6.8 μM/kg (p.o.).
Administration:i.v. and p.o.
Result:1.19Pharmacokinetic Parameters of AZD4747 in Cross Species[1].
MouseRat
IVaPOaIVaPOa
Eh (%)5275
Vss (L/kg)2.91.7
T1/2 (h)0.630.56
F%5818
Note:
a: 5% DMSO, 95% SBE-B-CD (30% w/v) in water.
References[1] Kettle JG, et al. Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration. J Med Chem. 2023 Jul 13;66(13):9147-9160. DOI:10.1021/acs.jmedchem.3c00746
AZD4747 Preparation Products And Raw materials
Tag:AZD4747(2489226-14-2) Related Product Information
2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- Y-27632 1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- RMC6291 RMC-7977 EHT1864