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| | 4-Deoxypyridoxine hydrochloride Basic information |
| | 4-Deoxypyridoxine hydrochloride Chemical Properties |
| Melting point | 274°C(dec.)(lit.) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated) | | form | Solid | | color | White to Pale Red | | biological source | synthetic (organic) | | Stability: | Hygroscopic | | Major Application | forensics and toxicology
veterinary
vitamins, nutraceuticals, and natural products | | InChI | 1S/C8H11NO2.ClH/c1-5-7(4-10)3-9-6(2)8(5)11;/h3,10-11H,4H2,1-2H3;1H | | InChIKey | QZKKOQQIVLXUEI-UHFFFAOYSA-N | | SMILES | Cl.Cc1ncc(CO)c(C)c1O | | CAS DataBase Reference | 148-51-6(CAS DataBase Reference) |
| WGK Germany | 3 | | RTECS | UT4800000 | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Toxicity | LD50 oral in chicken: 1570mg/kg |
| | 4-Deoxypyridoxine hydrochloride Usage And Synthesis |
| Description | 4-deoxy Pyridoxine (DOP) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells. DOP (5 mg, i.p.) reduces lysyl oxidase activity by 26% and reduces collagen and elastin crosslinking, resulting in limb abnormalities in chick embryos. It decreases latency to first seizure in mice (ED50 = 1 mmol/kg) and increases the occurrence and duration of myoclonic responses in baboons with photosensitive epilepsy. DOP reduces TNF-α and IL-6 production in mice infected with T. spiralis. | | Chemical Properties | Solid | | Uses | 4-Deoxypyridoxine is the deoxy analogue of Pyridoxine (P991735). 4-Deoxypyridoxine is a vitamin B6 antimetabolite; 4-Deoxypyridoxine can induce a deficient status that alters the function and ultrastructure of EC similar to vascular disease. | | References | [1] B SHANE E E S. Transport and metabolism of vitamin B6 in the yeast Saccharomyces carlsbergensis 4228.[J]. The Journal of Biological Chemistry, 1976, 251 4: 1042-1051.
[2] VIDYANI SURYADEVARA. Sphingolipids in Ventilator Induced Lung Injury: Role of Sphingosine-1-Phosphate Lyase.[J]. ACS Applied Materials & Interfaces, 2018. DOI: 10.3390/ijms19010114
[3] T A BIRD C I L. The effect of a vitamin B-6 antagonist, 4-deoxypyridoxine, on the cross-linking of collagen in the developing chick embryo.[J]. Biochemical Journal, 1983, 210 3: 633-638. DOI: 10.1042/bj2100633
[4] R. W. HORTON B. S M. Seizures induced by allylglycine, 3-mercaptopropionic acid and 4-deoxypyridoxine in mice and photosensitive baboons, and different modes of inhibition of cerebral glutamic acid decarboxylase[J]. British Journal of Pharmacology, 1973, 49 1: 52-63. DOI: 10.1111/j.1476-5381.1973.tb08267.x
[5] STAVROS FRYDAS . Generation of TNFα, IFNγ, IL-6, IL-4 and IL-10 in mouse serum from trichinellosis: effect of the anti-inflammatory compound 4-deoxypyridoxine (4-DPD)[J]. Immunology letters, 1996, 49 3: Pages 179-184. DOI: 10.1016/0165-2478(96)02501-1 |
| | 4-Deoxypyridoxine hydrochloride Preparation Products And Raw materials |
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