4-(2-Pyridinyl)phenylboronic acid pinacol ester manufacturers
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| | 4-(2-Pyridinyl)phenylboronic acid pinacol ester Basic information |
| Product Name: | 4-(2-Pyridinyl)phenylboronic acid pinacol ester | | Synonyms: | 4-(2-PYRIDINYL)PHENYLBORONIC ACID PINACOL ESTER;2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine;2-(4-Phenylboronic acid pinacol ester)pyridine;Pinacol 4-(pyridin-2-yl)phenylboronate;4-(2-Pyridinyl)phenylboronic acid, pinacol ester 98%;4-(2-Pyridyl)phenylboronic Acid Pinacol Ester;Pyridine, 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]- | | CAS: | 908350-80-1 | | MF: | C17H20BNO2 | | MW: | 281.16 | | EINECS: | | | Product Categories: | | | Mol File: | 908350-80-1.mol |  |
| | 4-(2-Pyridinyl)phenylboronic acid pinacol ester Chemical Properties |
| Boiling point | 403.9±28.0 °C(Predicted) | | density | 1.09 | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 4.34±0.10(Predicted) | | form | solid | | color | Off-white |
| | 4-(2-Pyridinyl)phenylboronic acid pinacol ester Usage And Synthesis |
| Chemical Properties | off-white powder | | Synthesis | General procedure for the synthesis of 4-(2-pyridyl)phenylboronic acid pinacol ester from isopropanol pinacol borate: 2-(4'-bromophenyl)pyridine (0.468 g, 2 mmol) was dissolved in anhydrous tetrahydrofuran (10 mL) and cooled to -78 °C. At this temperature, n-butyllithium (3 mL, 3.6 mmol) was slowly added dropwise, and stirring of the reaction mixture was continued for 1 hour after completion of the drop. Subsequently, 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (0.52 mL, 2.5 mmol) was added and the reaction mixture was stirred overnight. Upon completion of the reaction, the reaction was quenched with water and extracted three times with dichloromethane (30 mL). The organic layers were combined, washed with brine and dried over anhydrous magnesium sulfate. After purification by column chromatography (silica gel, eluent ethyl acetate:hexane=1:20), the target product 4-(2-pyridyl)phenylboronic acid pinacol ester was obtained as 0.22 g in 39% yield. Finally, the product was concentrated under vacuum. | | References | [1] Patent: WO2006/93466, 2006, A1. Location in patent: Page/Page column 40 |
| | 4-(2-Pyridinyl)phenylboronic acid pinacol ester Preparation Products And Raw materials |
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