|
|
| | 2-Boc-amino-4-formylpyridine Basic information |
| Product Name: | 2-Boc-amino-4-formylpyridine | | Synonyms: | 2-Boc-amino-4-formylpyridine;N-(4-Formyl-2-pyridinyl)carbamic acid tert-butyl ester;tert-butyl 4-forMylpyridin-2-ylcarbaMate;2-Boc-amino-4-formylpyridin;(4-Formyl-pyridin-2-yl)-carbamic acid tert-butyl ester;Carbamic acid, N-(4-formyl-2-pyridinyl)-, 1,1-dimethylethyl ester;2-[N,N-mono-(tert-butoxycarbonyl)amino]-pyridyl-4-aldehyde;tert-butyl N-(4-formyl-2-pyridyl)carbamate | | CAS: | 304873-65-2 | | MF: | C11H14N2O3 | | MW: | 222.24 | | EINECS: | | | Product Categories: | pharmacetical | | Mol File: | 304873-65-2.mol |  |
| | 2-Boc-amino-4-formylpyridine Chemical Properties |
| Melting point | 125-126℃ | | Boiling point | 308.8±27.0 °C(Predicted) | | density | 1.212 | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 12.20±0.70(Predicted) | | Appearance | White to off-white Solid |
| | 2-Boc-amino-4-formylpyridine Usage And Synthesis |
| Synthesis | General procedure for the synthesis of tert-butyl (4-formylpyridin-2-yl)carbamate from (4-(hydroxymethyl)pyridin-2-yl)carbamate:
Synthesis of compound 2G: tert-butyl (4-formylpyridin-2-yl)carbamate
Compound 2F ((tert-butyl (4-(hydroxymethyl)pyridin-2-yl)carbamate, 2.5 g, 11.15 mmol, 1.00 eq.) was dissolved in dichloroethane (DCE, 25 mL) followed by addition of manganese dioxide (MnO2, 19.4 g, 223.14 mmol, 20.02 eq.). The reaction mixture was stirred at 70 °C overnight. Upon completion of the reaction, the solid catalyst was removed by filtration. The filtrate was concentrated to dryness under reduced pressure to afford 1.4 g (57% yield) of the target product compound 2G as a white solid. | | References | [1] Synthesis, 2007, # 16, p. 2529 - 2533
[2] Patent: WO2003/103669, 2003, A1. Location in patent: Page 21
[3] Patent: WO2008/108958, 2008, A2. Location in patent: Page/Page column 32
[4] Patent: WO2008/108957, 2008, A2. Location in patent: Page/Page column 30
[5] Patent: WO2018/209132, 2018, A1. Location in patent: Paragraph 0526 |
| | 2-Boc-amino-4-formylpyridine Preparation Products And Raw materials |
|