4,6-DIIODO-2-METHYLPYRIMIDINE

1780-26-3

66298-49-5

General procedure for the synthesis of 4,6-diiodo-2-methylpyrimidine from 4,6-dichloro-2-methylpyrimidine: Synthesis of the key intermediate 6-iodo-2-methylpyrimidin-4-ylamine (Part A): Potassium iodide (3.5 M aqueous solution, 30.0 mL) was added to a solution of acetone (150 mL) containing 4,6-dichloro-2-methylpyrimidine (5.00 g, 0.03 mol) and sodium iodide (23.0 g, 0.15 mol) at room temperature. The reaction mixture was stirred at room temperature for 16 hours before being poured into an ice-water mixture (about 1:1, 250 mL) and allowed to warm slowly to room temperature. The solid formed was collected by diafiltration and washed with deionized water. The solid was dried in air to give 4,6-diiodo-2-methylpyrimidine (9.80 g, 92% yield) as an off-white solid.LC-MS (m/z): 347 ([M+H]+).