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| | 7-Chloro-1H-indole-3-carbaldehyde Basic information |
| Product Name: | 7-Chloro-1H-indole-3-carbaldehyde | | Synonyms: | 7-CHLORO-3-FORMYLINDOLE;7-Chloro-3-indolecarboxaldehyde;1H-Indole-3-carboxaldehyde, 7-chloro-;7-Chloro-3-formyl-1H-indole;7-Chloroindole-3-carbaldehyde;7-CHLORO-1H-INDOLE-3-CARBALDEHYDE;7-chloro-3-formylindole, CAS 1008-07-7;7-Chloro-1H-indol-3-carbaldehyde | | CAS: | 1008-07-7 | | MF: | C9H6ClNO | | MW: | 179.6 | | EINECS: | | | Product Categories: | | | Mol File: | 1008-07-7.mol |  |
| | 7-Chloro-1H-indole-3-carbaldehyde Chemical Properties |
| Melting point | 181-182 °C(Solv: ethyl acetate (141-78-6)) | | Boiling point | 373.4±22.0 °C(Predicted) | | density | 1.431±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 13.92±0.30(Predicted) | | Appearance | White to yellow Solid |
| | 7-Chloro-1H-indole-3-carbaldehyde Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 7-chloro-1H-indole-3-aldehyde from 7-chloro-1H-indole was as follows: phosphoryl chloride (0.66 mL, 7 mmol) was slowly added dropwise to anhydrous DMF (5 mL) at 0 °C and under argon protection. Subsequently, a solution of 7-chloro-1H-indole (1 g, 6.6 mmol) dissolved in anhydrous DMF (15 mL) was added dropwise to the above mixture at room temperature. The reaction mixture was stirred continuously for 2 hours at room temperature. After completion of the reaction, the mixture was slowly poured into a mixture of ice water and saturated NaHCO3 solution and extracted with ethyl acetate. The organic phases were combined, washed with saturated NaCl solution (10 mL x 3), dried over anhydrous MgSO4, filtered and concentrated to give 990 mg of the target product 7-chloro-1H-indole-3-aldehyde as a yellow-orange solid in 83% yield. | | References | [1] Patent: US2005/119260, 2005, A1. Location in patent: Page/Page column 36 |
| | 7-Chloro-1H-indole-3-carbaldehyde Preparation Products And Raw materials |
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