Rp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt)

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Rp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt) Basic information
Product Name:Rp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt)
Synonyms:Rp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt);Rp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt)
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MW:0
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Mol File:Mol File
Rp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt) Structure
Rp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt) Chemical Properties
solubility Water: soluble
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Rp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt) Usage And Synthesis
DescriptionRp-Adenosine-5'-O-(1-thiotriphosphate) (Rp-ATP-α-S) is an isomer of the sulfur-containing nucleotide derivative ATP-α-S and an agonist of the purinergic P2Y1 receptor.1 It increases calcium mobilization in HEK293 cells expressing the human P2Y1 receptor (EC50 = 75 nM). Rp-ATP-α-S binds to washed isolated human platelets (Ki = 156 nM), inhibits ADP-induced aggregation of isolated human platelet-rich plasma (PRP; pA2 = 4.74), and inhibits cAMP production induced by prostaglandin E1 (PGE1; Item No. 13010) in isolated human PRP (pA2 = 5.26).2,3 It also induces relaxation of carbamoylcholine-preconstricted guinea pig taenia coli strips (EC50 = 56 nM).4 Rp-ATP-α-S has been used in the synthesis of cyclic dinucleotides that are recognized by bacterial riboswitches.5WARNING This product is not for human or veterinary use.
References[1] DAN T. MAJOR. Molecular Recognition in Purinergic Receptors. 2. Diastereoselectivity of the h-P2Y1-Receptor†[J]. Journal of Medicinal Chemistry, 2004, 47 18: 4405-4416. DOI: 10.1021/jm049771u
[2] ASHOK AGARWAL. Evaluation of the Binding to Fixed Platelets of Agonists and Antagonists of ADP-Induced Aggregation[J]. Thrombosis and haemostasis, 1989, 67 1: 1103-1106. DOI: 10.1055/s-0038-1647126
[3] N.J. CUSACK  S. M O H. ADENOSINE 5′-DIPHOSPHATE ANTAGONISTS AND HUMAN PLATELETS: NO EVIDENCE THAT AGGREGATION AND INHIBITION OF STIMULATED ADENYLATE CYCLASE ARE MEDIATED BY DIFFERENT RECEPTORS[J]. British Journal of Pharmacology, 1982, 76 1: 221-227. DOI: 10.1111/j.1476-5381.1982.tb09210.x
[4] G. BURNSTOCK  L. A M  N J Cusack. Effects of phosphorothioate analogues of ATP, ADP and AMP on guinea-pig taenia coli and urinary bladder[J]. British Journal of Pharmacology, 1984, 82 2: 369-374. DOI: 10.1111/j.1476-5381.1984.tb10771.x
[5] KATHERINE D LAUNER-FELTY  Scott A S. Enzymatic synthesis of cyclic dinucleotide analogs by a promiscuous cyclic-AMP-GMP synthetase and analysis of cyclic dinucleotide responsive riboswitches.[J]. Nucleic Acids Research, 2018: 2765-2776. DOI: 10.1093/nar/gky137
Rp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt) Preparation Products And Raw materials
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