- 4-Azabenzimidazole
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- $0.00 / 1KG
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2025-04-04
- CAS:273-21-2
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1Ton
- 4-Azabenzimidazole
-
- $1.00 / 1KG
-
2020-01-03
- CAS:273-21-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10000KGS
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| | 4-Azabenzimidazole Basic information |
| Product Name: | 4-Azabenzimidazole | | Synonyms: | 1-deazapurine;3,4-diazaindole;Imidazo/4,5-b/pyridine (4-Azabenzimidazole) and its derivatives;PBTFL44;7-azabenzimidazole;4-AZABENZIMIDAZOLE;1 H-IMIDAZO[4,5-B]PYRIDINE;TIMTEC-BB SBB004292 | | CAS: | 273-21-2 | | MF: | C6H5N3 | | MW: | 119.12 | | EINECS: | 205-987-3 | | Product Categories: | | | Mol File: | 273-21-2.mol |  |
| | 4-Azabenzimidazole Chemical Properties |
| Melting point | 148-151 °C (lit.) | | Boiling point | 140-150°C/0.1mm | | density | 1.2058 (rough estimate) | | refractive index | 1.5589 (estimate) | | Fp | 140-150°C/0.1mm | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Soluble in dimethylformamide. | | pka | 8.46±0.20(Predicted) | | form | powder | | Appearance | Off-white to light brown Solid | | BRN | 2600 | | InChI | 1S/C6H5N3/c1-2-5-6(7-3-1)9-4-8-5/h1-4H,(H,7,8,9) | | InChIKey | GAMYYCRTACQSBR-UHFFFAOYSA-N | | SMILES | c1cnc2nc[nH]c2c1 | | CAS DataBase Reference | 273-21-2(CAS DataBase Reference) | | EPA Substance Registry System | 1H-Imidazo[4,5-b]pyridine (273-21-2) |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | NJ5108000 | | HS Code | 2933998090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral | | Toxicity | mouse,LD50,intraperitoneal,> 200mg/kg (200mg/kg),Journal of Medicinal Chemistry. Vol. 6, Pg. 480, 1963. |
| | 4-Azabenzimidazole Usage And Synthesis |
| Chemical Properties | yellow to light brown powder | | Uses | 4-Azabenzimidazole is used in the preparation of imidazo[4,5-b]pyridine 4-oxide. It is also used as a reagent to prepare benzoylmethyl-substituted azoles which are inhibitors of nitric oxide synthase with antioxidant properties. | | Definition | ChEBI: The [4,5-b]-fused isomer of imidazopyridine. | | Synthesis | The general procedure for the synthesis of 4-azabenzimidazole from 2,3-diaminopyridine and triethyl orthoformate was as follows: to evaluate the catalytic performance of different γ-Fe2O3@SiO2-HA catalysts, a catalytic amount of γ-Fe2O3@SiO2-HA (2.5 mol%) was added to a glass flask containing 1.2 mmol of triethyl orthoformate and stirred at room temperature for 15 minutes. Subsequently, 2 mmol of 2,3-diaminopyridine was added to the reaction mixture and the reaction was continued until a predetermined time was reached. The progress of the reaction was monitored by thin layer chromatography (TLC) and the unfolding agent was a solvent mixture of hexane and ethyl acetate (ratio 4:1 or 7:3 for diamines). Upon completion of the reaction, 5 mL of dichloromethane (ethyl acetate was used for entries 8 and 9) was added to the mixture, followed by separation of the catalyst by an external magnet for subsequent use. Finally, the resulting solution was concentrated on a rotary evaporator to give the purified 4-azabenzimidazole solid product. | | References | [1] Asian Journal of Chemistry, 2013, vol. 25, # 6, p. 3446 - 3448
[2] Journal of Molecular Structure, 2012, vol. 1027, p. 156 - 161 |
| | 4-Azabenzimidazole Preparation Products And Raw materials |
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