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| | TYRPHOSTIN B44 Basic information |
| Product Name: | TYRPHOSTIN B44 | | Synonyms: | (R)-(E)-2-CYANO-3-(3',4'-DIHYDROXYPHENYL)-N-(1-PHENYLETHYL)-2-PROPENAMIDE;(-)-(R)-N-(ALPHA-METHYLBENZYL)-3,4-DIHYDROXY-BENZYLIDENECYANOACETAMIDE;(-)-(R)-N-(ALPHA-METHYLBENZYL)-3,4-DIHYDROXYBENZYLIDINECYANOACETAMIDE;TYRPHOSTIN AG 527;TYRPHOSTIN B44;TYRPHOSTIN B44(-);TRYPHOSTIN AG 527;(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1R)-1-phenylethyl]-2-propenamide | | CAS: | 133550-32-0 | | MF: | C18H16N2O3 | | MW: | 308.33 | | EINECS: | | | Product Categories: | Intracellular Signaling;Protein Kinase | | Mol File: | 133550-32-0.mol |  |
| | TYRPHOSTIN B44 Chemical Properties |
| Boiling point | 603.0±55.0 °C(Predicted) | | density | 1.299±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMSO or ethanol: soluble | | form | Yellow solid. | | pka | 8.81±0.10(Predicted) |
| | TYRPHOSTIN B44 Usage And Synthesis |
| Uses | Tyrphostin B44, (-) enantiomer is a potent inhibitor of (EGFR) kinase. | | Biological Activity | Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC 50 = 0.4 μ M), more active than the (+) enantiomer ((S)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide ). Selective over ErbB2. |
| | TYRPHOSTIN B44 Preparation Products And Raw materials |
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