2-(2-Pyridinyl)-(3H)-indol-3-one-1-oxide 4-methylbenzenesulfonate

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2-(2-Pyridinyl)-(3H)-indol-3-one-1-oxide 4-methylbenzenesulfonate Basic information
Product Name:2-(2-Pyridinyl)-(3H)-indol-3-one-1-oxide 4-methylbenzenesulfonate
Synonyms:PIT;2,2'-pyridylisatogen tosylate;2-(2-Pyridinyl)-(3H)-indol-3-one-1-oxide 4-methylbenzenesulfonate
CAS:56583-49-4
MF:C20H16N2O5S
MW:396.42
EINECS:
Product Categories:
Mol File:56583-49-4.mol
2-(2-Pyridinyl)-(3H)-indol-3-one-1-oxide 4-methylbenzenesulfonate Structure
2-(2-Pyridinyl)-(3H)-indol-3-one-1-oxide 4-methylbenzenesulfonate Chemical Properties
storage temp. Desiccate at +4°C
solubility Soluble to 15 mM in ethanol with gentle warming and to 80 mM in DMSO
form Powder
color Brown to reddish brown
Safety Information
MSDS Information
2-(2-Pyridinyl)-(3H)-indol-3-one-1-oxide 4-methylbenzenesulfonate Usage And Synthesis
UsesPIT is a purinergic P2Y receptor ligand.
Biological ActivityPurinergic P2Y receptor ligand. Displays irreversible antagonism at P2Y receptors in some smooth muscles but potentiates responses to ATP in other systems (chick brain recombinant P2Y 1 receptor and sympathetic/purinergic nerve stimulation).
in vivo

PIT (10 mg/kg; i.p.; for 5 days) significantly protects both the white matter and the cortical plate lesions against the insult in mice with S-bromo-willardiine injection induced tonic and tonicoclonic seizures[3].

IC 50P2Y1 Receptor: 0.14 μM μM (IC50)
2-(2-Pyridinyl)-(3H)-indol-3-one-1-oxide 4-methylbenzenesulfonate Preparation Products And Raw materials
Tag:2-(2-Pyridinyl)-(3H)-indol-3-one-1-oxide 4-methylbenzenesulfonate(56583-49-4) Related Product Information
1-Phenyl-1,2-propanedione-2-oxime 2-Isonitrosoacetophenone 2-(2-pyridin-2-ylethyl)aniline 2-(2-Pyridinyl)-(3H)-indol-3-one-1-oxide 4-methylbenzenesulfonate 2,2'-pyridylisatogen Prasugrel