8-(4-Chlorophenylthio)guanosine 3',5'-cyclic monophosphothioate, RP-isomer triethylammonium salt

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8-(4-Chlorophenylthio)guanosine 3',5'-cyclic monophosphothioate, RP-isomer triethylammonium salt Basic information
Product Name:8-(4-Chlorophenylthio)guanosine 3',5'-cyclic monophosphothioate, RP-isomer triethylammonium salt
Synonyms:RP-8-[(4-CHLOROPHENYL)THIO]-GUANOSINE-CYCLIC 3',5'-HYDROGEN PHOSPHOROTHIOATE TRIETHYLAMINE;RP-8-PCPT-CGMPS;RP-8-PCPT-CGMPS SODIUM SALT;RP-8-PCPT-CGMPS, TEA;RP-8-P-CPT-CGMPS TRIETHYLAMINE;8-(4-CHLOROPHENYLTHIO) GUANOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT;8-(4-CHLOROPHENYLTHIO)GUANOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT, RP-ISOMER;8-(4-CHLOROPHENYLTHIO)GUANOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE, RP-ISOMER SODIUM SALT
CAS:153660-04-9
MF:C16H15ClN5O6PS2
MW:503.88
EINECS:
Product Categories:
Mol File:153660-04-9.mol
8-(4-Chlorophenylthio)guanosine 3',5'-cyclic monophosphothioate, RP-isomer triethylammonium salt Structure
8-(4-Chlorophenylthio)guanosine 3',5'-cyclic monophosphothioate, RP-isomer triethylammonium salt Chemical Properties
storage temp. −20°C
solubility H2O: 5 mg/mL
form solid
color white
Water Solubility water: 0.5mg/mL
DMSO: soluble
Safety Information
Safety Statements 22-24/25
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
8-(4-Chlorophenylthio)guanosine 3',5'-cyclic monophosphothioate, RP-isomer triethylammonium salt Usage And Synthesis
UsesRp-8-pCPT-cGMPS is a competitive inhibitor of cGMP-dependent protein kinase (PKG) (Ki=0.5 μM). Rp-8-pCPT-cGMPS has high lipid solubility and can more easily penetrate the cell membrane and reach sufficient concentration inside the cell to inhibit cGMP-dependent protein kinase. Rp-8-pCPT-cGMPS can be used to study the activity and function of cGMP-dependent protein kinase in platelets[1].
Biological ActivityCell permeable: yes', 'Primary Target
PKG1α', 'Product does not compete with ATP.', 'Reversible: no
References[1] E Butt, et al. (Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor. European Journal of Pharmacology: Molecular Pharmacology 269.2 (1994): 265-268. DOI:10.1016/0922-4106(94)90095-7
8-(4-Chlorophenylthio)guanosine 3',5'-cyclic monophosphothioate, RP-isomer triethylammonium salt Preparation Products And Raw materials
Tag:8-(4-Chlorophenylthio)guanosine 3',5'-cyclic monophosphothioate, RP-isomer triethylammonium salt(153660-04-9) Related Product Information
Guanosine 3',5'-cyclic monophosphorothioate, RP-isomer, triethylammonium salt 5-Amino-2-mercapto-1-methyl-1H-imidazole-4-carboxamide GUANOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT SODIUM O,O-DIETHYLTHIOPHOSPHATE PHOSPHOROTHIOATE guanine hydrochloride 5-AMINO-1-METHYL-2-(METHYLTHIO)-1H-IMIDAZOLE-4-CARBOXAMIDE sodium O,O-dimethyl thiophosphate 8-(4-CHLOROPHENYLTHIO)GUANOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE, RP-ISOMER TRIETHYLAMMONIUM SALT 8-MERCAPTOGUANOSINE