8-MERCAPTOGUANOSINE manufacturers
|
| | 8-MERCAPTOGUANOSINE Basic information |
| Product Name: | 8-MERCAPTOGUANOSINE | | Synonyms: | 8-THIOGUANOSINE;8-MERCAPTOGUANOSINE;8-MERCAPTOGUANOSINE HYDRATE;8-Mercapto-7,8-dihydroguanosin;Nsc79216;7,8-dihydro-8-thioxoguanosine;SQ 12760;8-Tio-Guanosine | | CAS: | 26001-38-7 | | MF: | C10H13N5O5S | | MW: | 315.31 | | EINECS: | 247-402-4 | | Product Categories: | | | Mol File: | 26001-38-7.mol |  |
| | 8-MERCAPTOGUANOSINE Chemical Properties |
| Melting point | >220 °C | | density | 2.35±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO (Slightly) | | pka | 6.15±0.20(Predicted) | | form | crystalline | | color | light yellow | | Stability: | Hygroscopic |
| WGK Germany | 3 | | HS Code | 29389090 |
| | 8-MERCAPTOGUANOSINE Usage And Synthesis |
| Chemical Properties | Light yellow fine crystalline powder | | Uses | 8-Mercaptoguanosine is an immunoadjuvant that affects the in vivo antibody response to the T-cell-independent antigen TNP-Ficoll. 8-Mercaptoguanosine enhances IgG1, IgG2, and IgG3 antibody responses, but has no effect on IgM antibody responses. 8-Mercaptoguanosine also enhances antibody responses to very weak antigens such as pneumococcal polysaccharide and restores antibody responses in immunodeficient xid mice that are non-reactive to TNP-Ficoll[1][2]. | | References | [1] Mond JJ, Hunter K, Kenny JJ, Finkelman F, Witherspoon K. 8-Mercaptoguanosine-mediated enhancement of in vivo IgG1, IgG2 and IgG3 antibody responses to polysaccharide antigens in normal and xid mice. Immunopharmacology. 1989 Nov-Dec;18(3):205-12. DOI:10.1016/0162-3109(89)90018-0
[2] Feldbush TL, Ballas ZK. Lymphokine-like activity of 8-mercaptoguanosine: induction of T and B cell differentiation. J Immunol. 1985 May;134(5):3204-11. PMID:3872330 |
| | 8-MERCAPTOGUANOSINE Preparation Products And Raw materials |
|