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| | Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 trifluoroacetate salt Basic information |
| Product Name: | Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 trifluoroacetate salt | | Synonyms: | MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS: DNP-NH2 [MCA-RPKPYA-NVA-WM-K: DNP-NH2];MCA-ARG-PRO-LYS-PRO-VAL-GLU-NVA-TRP-ARG-LYS: DNP-NH2 [MCA-RPKPVE-NVA-WRK: DNP-NH2];7-methoxycoumarin-4-acetyl-arg-pro-*lys-pro-val-G;7-METHOXYCOUMARIN-4-ACETYL-ARG-PRO-*LYS- PRO-VAL-GLU;Mca-RPKPVE-Nva-WR-Lys(Dnp)-NH2;7-METHOXYCOUMARIN-4-ACETYL-ARG-PRO-LYS-PRO-VAL-GLU-NVA-TRP-ARG-(2,4-DINITROPHENYL)-LYS AMIDE;7-METHOXYCOUMARIN-4-ACETYL-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-(2,4-DINITROPHENYL)-LYS AMIDE;(7-METHOXYCOUMARIN-4-YL)ACETYL-L-ARGINYL-L-PROLYL-L-LYSYL-L-PROLYL-L-TYROSYL-L-ALANYL-L-NORVALYL-L-TRYPTOPHYL-L-METHIONYL-N-EPSILON-(2,4-DINITROPHENYL)-L-LYSINE AMIDE | | CAS: | 158584-09-9 | | MF: | C78H110N22O20 | | MW: | 1675.85 | | EINECS: | | | Product Categories: | peptide;Activity;Enzyme Substrates;Fluorogenic | | Mol File: | 158584-09-9.mol |  |
| | Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 trifluoroacetate salt Chemical Properties |
| density | 1.49±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMF: 25 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: slightly soluble | | form | A crystalline solid | | pka | 4.44±0.10(Predicted) | | color | yellow | | Sequence | {Mca}-Arg-Pro-Lys-Pro-Val-Glu-{Nva}-Trp-Arg-Lys(DNP)-NH2 |
| | Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 trifluoroacetate salt Usage And Synthesis |
| Uses | NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity[1]. | | Biological Activity | Cell permeable: no', 'Primary Target
Matrix Metalloproteinases (MMPs)', 'Product does not compete with ATP.', 'Reversible: no', 'kcat/Km = 5.9 x 104 M-1sec-1 as substrates for MMP-3 (stromelysin-1) | | IC 50 | MMP-3; MMP-10 | | References | [1] Giricz O, et al. Comparison of metalloproteinase protein and activity profiling. Anal Biochem. 2011 Feb 1;409(1):37-45. DOI:10.1016/j.ab.2010.09.040 |
| | Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 trifluoroacetate salt Preparation Products And Raw materials |
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