1-(4-Bromobenzyl)indole-2,3-dione manufacturers
- VU0119498
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- $50.00
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2026-08-08
- CAS:79183-37-2
- Purity: 97.56%
- Supply Ability: 10g
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| | 1-(4-Bromobenzyl)indole-2,3-dione Basic information |
| Product Name: | 1-(4-Bromobenzyl)indole-2,3-dione | | Synonyms: | VU0119498;1-(4-bromobenzyl)-1H-indole-2,3-dione;1H-Indole-2,3-dione, 1-[(4-bromophenyl)methyl]-;antidiabetic,VU 0119498,Inhibitor,VU0119498,inhibit,VU-0119498,mAChR,pan,Muscarinic acetylcholine receptor;VU0119498, M1 muscarinic receptor agonist and pan mAChR M3, M5 PAM;VU0119498, 10 mM in DMSO;1-[(4-Bromophenyl)methyl]indole-2,3-dione;VU0119498 ，S0783 | | CAS: | 79183-37-2 | | MF: | C15H10BrNO2 | | MW: | 316.15 | | EINECS: | | | Product Categories: | | | Mol File: | 79183-37-2.mol |  |
| | 1-(4-Bromobenzyl)indole-2,3-dione Chemical Properties |
| Melting point | 178-180 °C | | Boiling point | 469.2±47.0 °C(Predicted) | | density | 1.604±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO: 50 mg/mL (158.15 mM) | | form | A solid | | pka | -2.61±0.20(Predicted) | | color | Orange to red |
| | 1-(4-Bromobenzyl)indole-2,3-dione Usage And Synthesis |
| Uses | VU0119498 is a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM), with EC50s of 6.04, 6.38, and 4.08 μM, respectively. VU0119498 has antidiabetic activity[1][2][3]. | | in vivo | VU0119498 (0.1-2 mg/kg; a single i.p.) improves glucose tolerance and insulin secretion in mice in a β-cell M3R-dependent fashion[3].
VU0119498 (0.5 mg/kg; a single i.p.) improves glucose tolerance and insulin secretion in obese, glucose-intolerant mice[3]. | Animal Model: | Male WT mice (12 weeks)[3] | | Dosage: | 0.1, 0.5, 2 mg/kg | | Administration: | A single i.p. | | Result: | Caused a significant improvement in glucose tolerance at the dose of 0.5 mg/kg.
Significantly augmented GSIS at the dose of 0.5 mg/kg.
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| | References | [1] Bridges TM, et, al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem. 2009 Jun 11;52(11):3445-8. DOI:10.1021/jm900286j
[2] Bridges TM, et, al. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1972-5. DOI:10.1016/j.bmcl.2010.01.109
[3] Zhu L, et, al. Allosteric modulation of β-cell M 3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18684-18690. DOI:10.1073/pnas.1904943116 |
| | 1-(4-Bromobenzyl)indole-2,3-dione Preparation Products And Raw materials |
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