- AC-55541
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- $34.00 / 5mg
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2026-04-22
- CAS:916170-19-9
- Min. Order:
- Purity: 98.00%
- Supply Ability: 10g
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| | AC-55541 Basic information |
| Product Name: | AC-55541 | | Synonyms: | (2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide;AC 55541;CS-2020;CS-1802;AC 55541,(2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide;(E)-N-(2-(2-(1-(3-Bromophenyl)ethylidene)hydrazinyl)-2-oxo-1-(4-oxo-3,4-dihydrophthalazin-1-yl)ethyl)benzamide;AC55541; AC-55541;(2E)-2-[1-(3-Bromophenyl)ethylidene] α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid hydrazide AC55541 | | CAS: | 916170-19-9 | | MF: | C25H20BrN5O3 | | MW: | 518.36 | | EINECS: | 604-604-1 | | Product Categories: | Inhibitors | | Mol File: | 916170-19-9.mol |  |
| | AC-55541 Chemical Properties |
| density | 1.49±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | Soluble in DMSO | | form | powder | | pka | 10.99±0.46(Predicted) | | color | White to off-white |
| | AC-55541 Usage And Synthesis |
| Uses | AC 55541 is a selective protease-activated receptor 2 agonist. | | Definition | ChEBI: AC-55541 is an organic molecular entity. | | Biological Activity | ac 55541 is a potent agonist of par2 with pec50 value of 6.7 and functions range from 200 to 1000 nm [1-3].protease-activated receptor 2 (par2) is a member of the large family of 7-transmembrane receptors and plays an important role in modulating inflammatory responses and acting as a sensor for proteolytic enzymes generated during infection [2].ac 55541 is a selective par2 agonist and has no effect on par1. using a cellular proliferation assay (r-sat), it showed that ac 55541 stimulated nih-3t3 cells proliferation by activating par2 and receptor with f240s mutation constitutively active in all functional assays which nearly 30-fold sensitive to ac 55541 than sligrl and 2-furorl ligrlo [1, 2]. when tested with human corneal epithelial (hce) cells, administration of ac 55541 significantly induced the expression of par2 and inhibited acanthamoeba plasminogen activator (apa) [3].in male sprague-dawley rat model with acute thermal nociception and edema in paw induced by sligrl-nh2 or trypsin, intrapaw administration of ac 55541 induced hind paw edema and thermal hyperalgesia at the doses as low as 30 ng and showed dose-dependent pronociceptive effects [1]. | | IC 50 | PAR2 | | storage | Store at -20°C | | references | 1. gardell, l.r., et al., identification and characterization of novel small-molecule protease-activated receptor 2 agonists. j pharmacol exp ther, 2008. 327(3): p. 799-808.2. ma, j.n. and e.s. burstein, the protease activated receptor 2 (par2) polymorphic variant f240s constitutively activates par2 receptors and potentiates responses to small-molecule par2 agonists. j pharmacol exp ther, 2013. 347(3): p. 697-704.3. tripathi, t., m. abdi, and h. alizadeh, protease-activated receptor 2 (par2) is upregulated by acanthamoeba plasminogen activator (apa) and induces proinflammatory cytokine in human corneal epithelial cells. invest ophthalmol vis sci, 2014. 55(6): p. 3912-21. |
| | AC-55541 Preparation Products And Raw materials |
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