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| | tert-Butyl (1-(Methylsulfonyl)piperidin-4-yl)carbaMate Basic information |
| Product Name: | tert-Butyl (1-(Methylsulfonyl)piperidin-4-yl)carbaMate | | Synonyms: | tert-Butyl (1-(Methylsulfonyl)piperidin-4-yl)carbaMate;[1-(Methylsulfonyl)piperidin-4-yl]carbamic acid tert-butyl ester;Carbamic acid, N-[1-(methylsulfonyl)-4-piperidinyl]-, 1,1-dimethylethyl ester;tert-butyl N-(1-methylsulfonylpiperidin-4-yl)carbamate | | CAS: | 287953-38-2 | | MF: | C11H22N2O4S | | MW: | 278.37 | | EINECS: | | | Product Categories: | | | Mol File: | 287953-38-2.mol |  |
| | tert-Butyl (1-(Methylsulfonyl)piperidin-4-yl)carbaMate Chemical Properties |
| density | 1.21±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 12.12±0.20(Predicted) |
| | tert-Butyl (1-(Methylsulfonyl)piperidin-4-yl)carbaMate Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 1-methanesulfonyl-4-tert-butoxycarbonylaminopiperidine from methanesulfonyl chloride and 4-tert-butoxycarbonylaminopiperidine: 5.00 g (25.0 mmol) of Boc-4-aminopiperidine was dissolved in 19.8 mL of pyridine and cooled in an ice bath. 2.13 mL (27.5 mmol) of methanesulfonyl chloride was added slowly and dropwise. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the reaction mixture was diluted with water and then extracted with dichloromethane (DCM). The organic layer was washed with water, dried over anhydrous magnesium sulfate (MgSO4) and filtered. The solvent was removed by concentration under reduced pressure to give 6.30 g of tert-butyl 1-methanesulfonyl-piperidin-4-yl-carbamate. The yield was 91%; ESI-MS: 279 [M + H]+. | | References | [1] Patent: WO2014/184327, 2014, A1. Location in patent: Page/Page column 27
[2] Patent: WO2006/77414, 2006, A1. Location in patent: Page/Page column 163-164
[3] Bioorganic Chemistry, 2015, vol. 61, p. 21 - 27
[4] Journal of Medicinal Chemistry, 2006, vol. 49, # 22, p. 6549 - 6560
[5] Patent: US2006/14708, 2006, A1. Location in patent: Page/Page column 13 |
| | tert-Butyl (1-(Methylsulfonyl)piperidin-4-yl)carbaMate Preparation Products And Raw materials |
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