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5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride

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Company Name: CANGZHOU SENARY CHEMICAL S&T CO.,LTD  Gold
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Products Intro: Product Name:4,5,6,7-tetrahydro-5-methyl-thiazolo[5,4-c]pyridin-2-carboxylic acid hydrochloride
CAS:720720-96-7
Purity:99% HPLC Package:25KG
Company Name: Jiangsu Vcare PharmaTech Co., Ltd.  Gold
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Products Intro: Product Name:Thiazolo[5,4-c]pyridine-2-carboxylic acid, 4,5,6,7-tetrahydro-5-Methyl-, hydrochloride (1:1)
CAS:720720-96-7
Company Name: Jinan Lide Pharmaceutical Technology Co., Ltd.  Gold
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Products Intro: Product Name:4,5,6,7-tetrahydro-5-methyl-Thiazolo[5,4-c]pyridine-2-carboxylic acid, hydrochloride (1:1)
CAS:720720-96-7
Purity:99 Package:1kg/
Company Name: Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd  Gold
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Products Intro: Product Name:5-Methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
CAS:720720-96-7
Purity:99% Package:25kg
Company Name: Beijing Huize Zhongsen Pharmaceutical Technology Co., Ltd.  Gold
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Products Intro: Product Name:4,5,6,7-tetrahydro-5-methyl-Thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
CAS:720720-96-7
Purity:99% Package:1kg;10吨

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride manufacturers
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Basic information
Product Name:5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
Synonyms:4,5,6,7-tetrahydro-5-Methyl-Thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride;5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride;EthanediaMide iMpurity B HCL;5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride;Thiazolo[5,4-c]pyridine-2-carboxylic acid, 4,5,6,7-tetrahydro-5-Methyl-, hydrochloride (1:1);5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride(for Edoxaban);4,5,6,7-tetrahydro-5-Methyl-Thiazolo[5,4-c]pyridin;4,5,6,7-tetrahydro-5-Methyl-Thiazolo[5,4-c]pyridine-2-carboxylic acid HCl
CAS:720720-96-7
MF:C8H11ClN2O2S
MW:234.7
EINECS:858-363-3
Product Categories:
Mol File:720720-96-7.mol
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Structure
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Chemical Properties
Melting point 199.0 to 203.0 °C
Boiling point 175℃[at 101 325 Pa]
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Very Slightly)
form Solid
color Pale Beige to Light Brown
Stability:Hygroscopic
InChIInChI=1S/C8H10N2O2S.ClH/c1-10-3-2-5-6(4-10)13-7(9-5)8(11)12;/h2-4H2,1H3,(H,11,12);1H
InChIKeyZWIYEBIMFPQYDI-UHFFFAOYSA-N
SMILESC(C1SC2CN(C)CCC=2N=1)(=O)O.Cl
Safety Information
HS Code 2934.10.2000
MSDS Information
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Usage And Synthesis
Uses5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is used as a reagent in the synthesis of N-(2-acylaminobenzyl or 2-acylaminoheterocyclylmethyl)thiophene-2-carboxamide derivatives as antithrombotics. It is also used as a reagent in the synthesis of diamide derivatives as FXa inhibitors. 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is an intermediate for Edoxaban (E555520).
Preparation2-cyano-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine hydrochloride monohydrate (500.61 mg), ethanol (5 mL), and 4N aqueous lithium hydroxide (1.34 mL) were mixed at room temperature, and the resultant mixture was stirred at 50 °C for 7 hours. Until the reaction mixture was cooled with ice-water, 1N HCl in ethanol (7.5 mL) was added to the mixture. It was stirred for 1.5 hours. The precipitated crystals were collected by filtration, and were washed with ethanol (2 mL). The wet crystal was dried at room temperature under reduced pressure to obtain 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride.
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride Preparation Products And Raw materials
Raw materials4-Piperidinone, 3-broMo-1-Methyl-, hydrobroMide-->Thiazolo[5,4-c]pyridine, 4,5,6,7-tetrahydro-5-methyl--->2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-->Edoxaban Impurity 29-->1-Methyl-4-piperidone
Preparation Productsedoxaban
Tag:5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride(720720-96-7) Related Product Information
EthanediaMide, N1-(5-chlo... Thiazolo[5,4-c]pyridine, 4,5,6,7-tetrahydro-5-methyl- 2-(((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)amino)-2-oxoacetic acid (1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate N-(5-Chloropyridin-2-yl)oxalaMic acid ethyl ester edoxaban Edoxaban Edoxaban Impurity 8 Oxalic acid 1-ethyl ester Edoxaban Impurity 29 INDEX NAME NOT YET ASSIGNED Edoxaban-d6 Edoxaban Impurity 16 (1S,3S,4S)-3-AMino-4-hydroxy-cyclohexanecarboxylic acid ethyl ester EthanediaMide iMpurity D EthanediaMide, N1-(5-chlo... EthanediaMide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2S,4R)-4-[(diMethylaMino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-Methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]aMino]cyclohexyl]- (1S,3R,4S)-4-(2-((5-chloropyridin- 2-yl)amino)-2-oxoacetamido)-3-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexane-1-carboxylic acid