| Company Name: |
SPIRO PHARMA |
| Tel: |
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| Email: |
eric_feng1954@126.com |
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| | AICAR (phosphate) Basic information |
| Product Name: | AICAR (phosphate) | | Synonyms: | AICAR (Acadesine) phosphate;AICAR (phosphate);5-Amino-1-ribosylimidazole-4-carboxamide phosphate;AICAR phosphate, >98%;AICA Riboside phosphate);AICAR phosphate
(Acadesine phosphate;Acadesine phosphate;ACADESINE PHOSPHATE;AICA RIBOSIDE PHOSPHATE | | CAS: | 681006-28-0 | | MF: | C9H17N4O9P | | MW: | 356.23 | | EINECS: | | | Product Categories: | | | Mol File: | 681006-28-0.mol |  |
| | AICAR (phosphate) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | color | White to off-white |
| | AICAR (phosphate) Usage And Synthesis |
| Uses | AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor[1][2]. | | Biological Activity | aicar phosphate （acadesine）is an activator of ampk [1].aicar phosphate has been reported to induce apoptosis in a dose-dependent fashion and that the ec50 value is 380±60μm on the viability assay of b-cll cells. in addition, aicar phosphate has been revealed to induce caspase activation and cytochrome c release from mitochondria in b-cll cells. furthermore, aicar phosphate has shown that uptake and phosphorylation are required to induce apoptosis and activate ampk. apart from these, aicar phosphate (2-4 mm) has shown to only slightly affects the viability of t cells from b-cll patients, aicar phosphate (0.5 mm) has been noted to remarkedly reduces viability of b cells but not t cells [1]. | | in vivo | Fourteen-week-old male, lean (L; 31.3 g body wt) wild-type andob/ob (O; 59.6 g body wt) mice are injected with the AMP-activated kinase (AMPK) activator AICAR (A) at 0.5 mg*g body wt-1*day-1 or saline control (C) for 14 days. At 24 h after the last injection (including a 12-h fast), all mice are killed, and the plantar flexor complex muscle (gastrocnemius, soleus, and plantaris) is excised for analysis. Muscle mass is lower in OC (159±12 mg) than LC, LA, and OA (176±10, 178±9, and 166±16 mg, respectively) mice, independent of a body weight change[3]. The kidney weight is significantly higher in the untreated group when compared with both the exercise and AICAR (0.5 mg/g body wt) groups. The heart weight is higher in the exercise group than in the other groups, whereas the liver weight is significantly higher in the AICAR-treated group when compared with the exercise and untreated groups[4]. | | IC 50 | AMPK; Autophagy; Mitophagy; Human Endogenous Metabolite | | references | [1] campàs c1, lopez jm, santidrián af, barragán m, bellosillo b, colomer d, gil j. acadesine activates ampk and induces apoptosis in b-cell chronic lymphocytic leukemia cells but not in t lymphocytes. blood. 2003 may 1;101(9):3674-80. epub 2003 jan 9. |
| | AICAR (phosphate) Preparation Products And Raw materials |
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