AF38469 manufacturers
- AF38469
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- $89.00
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2026-07-17
- CAS:1531634-31-7
- Purity: 99.56%
- Supply Ability: 10g
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| | AF38469 Basic information |
| Product Name: | AF38469 | | Synonyms: | AF38469;AF38469
(AF-38469);CS-2561;Benzoic acid, 2-[[(6-methyl-2-pyridinyl)amino]carbonyl]-5-(trifluoromethyl)-;2-((6-Methylpyridin-2-yl)carbamoyl)-5-(trifluoromethyl)benzoic acid;inhibit,AF 38469,Neurotensin Receptor,Inhibitor,AF38469;2-[(6-Methyl-2-pyridyl)carbamoyl]-5-(trifluoromethyl)benzoic Acid;AF38469, 10 mM in DMSO | | CAS: | 1531634-31-7 | | MF: | C15H11F3N2O3 | | MW: | 324.25 | | EINECS: | | | Product Categories: | | | Mol File: | 1531634-31-7.mol |  |
| | AF38469 Chemical Properties |
| Boiling point | 392.3±42.0 °C(Predicted) | | density | 1.448±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: Soluble; Ethanol: Soluble | | form | A solid | | pka | 2.83±0.36(Predicted) | | color | Off-white to light yellow |
| | AF38469 Usage And Synthesis |
| Uses | AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM. | | in vivo | AF38469 (1 mg/kg; i.v.) has a low volume of distribution (blood volume of 0.7 L/kg) and low clearance (4.8 L/h/kg), and a half-life (t1/2) of 1.2 h in rat[1]. | | References | [1] Schroder TJ, et al. The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorg Med Chem Lett. 2014 Jan 1;24(1):177-80. DOI:10.1016/j.bmcl.2013.11.046 |
| | AF38469 Preparation Products And Raw materials |
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