N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride

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N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride Suppliers list
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:SB 699551 dihydrochloride
CAS:864741-95-7
Purity:96.53% Package:1mg;48USD|5mg;113USD|10mg;189USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
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Products Intro: Product Name:N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride
CAS:864741-95-7
Purity:95.0% windy 1096
Company Name: Aladdin Scientific
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Products Intro: Product Name:SB 699551 dihydrochloride
CAS:864741-95-7
Purity:96% Package:$59.9/1mg;$119.9/5mg;$219.9/10mg;$449.9/25mg;$799.9/50mg;Bulk package Remarks:96%
Company Name: Bide Pharmatech Ltd.  
Tel: 400-164-7117 18317119277
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Products Intro: Product Name:3-Cyclopentyl-N-(2-(dimethylamino)ethyl)-N-((4'-((phenethylamino)methyl)-[1,1'-biphenyl]-4-yl)methyl)propanamide dihydrochloride
CAS:864741-95-7
Purity:98% Package:1mg;5mg;10mg Remarks:BD00815914
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 13816613772
Email: huahero21@sina.com
Products Intro: Product Name:SB-699551
CAS:864741-95-7
Purity:98% HPLC Package:1g

N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride manufacturers
N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride Basic information
Product Name:N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride
Synonyms:SB 699551 dihydrochloride;3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[[4-[4-[(2-phenylethylamino)methyl]phenyl]phenyl]methyl]propanamide;3-Cyclopentyl-N-(2-(dimethylamino)ethyl)-N-((4'-((phenethylamino)methyl)-[1,1'-biphenyl]-4-yl)methyl)propanamide dihydrochloride;SB 699551 dihydrochloride, 5-HT5A receptor antagonist;3-Cyclopentyl-N-(2-(dimethylamino)ethyl)-N-((4'-((phenethylamino)methyl)-[1,1'-biphenyl]-4-yl)methyl)propanamide dihydrochloride
CAS:864741-95-7
MF:C34H46ClN3O
MW:548.21
EINECS:
Product Categories:
Mol File:864741-95-7.mol
N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride Structure
N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride Chemical Properties
storage temp. Inert atmosphere,2-8°C
solubility H2O: soluble1mg/mL, clear (warmed)
form powder
color white to beige
Water Solubility H2O: 1mg/mL, clear (warmed)
InChIKeyQJMKBIHLMPTYTI-UHFFFAOYSA-N
SMILESCl.Cl.N(CCN(Cc2ccc(cc2)c3ccc(cc3)CNCCc4ccccc4)C(=O)CCC1CCCC1)(C)C
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 46
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride Usage And Synthesis
UsesSB 699551 Dihydrochloride is a potent 5-HT5A receptor antagonist shown to mediate hypotension in anesthetized rats (1). May also be used as an antagonist in mediating the negative effects of schizophrenia. It is also used in the role of peripheral 5-HT5A receptors in 5-HT-induced cardiac sympatho-inhibition in type 1 diabetic rats.
Biological ActivitySB 699551 dihydrochloride is also known as (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4μ-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride). It is considered as a useful tool to explain the physiological roles of the 5-ht5A receptor.', 'SB-699551 is a 5-HT5A receptor antagonist, (pKi = 8.3) with 100-fold selectivity over other 5-HT receptor populations. SB-699551 completely blocks 5-HT-induced [35S]GTPγS membrane binding in cells expressing recombinant guinea pig 5-HT-5A.
in vivo

SB-699551 (25 mg/kg; i.p.; once daily; 3 weeks) reduced xenograft growth rate in a breast cancer xenograft model in NOD/SCID mice and synergized with Docetaxel to reduce xenograft size[3].
SB-699551 (0.3-3 mg/kg; i.p.; once) reversed drug-induced cognitive deficits in attention switching and novel object recognition tasks and improved social withdrawal in Sprague-Dawley rats[7].
SB-699551 (0.3-3 mg/kg; s.c.; once) co-treatment with Dizocilpine (HY-15084B) or Scopolamine (HY-N0296) reversed amnesia (long-term memory) in Wistar rats[8].

IC 505-HT5A Receptor: 8.3 (pKi)
storageStore at +4°C
N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride Preparation Products And Raw materials
Tag:N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride(864741-95-7) Related Product Information
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