N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride

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N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride manufacturers
N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride Basic information
Product Name:N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride
Synonyms:M8-B hydrochloride;N-(2-Aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride;N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride;2-Thiophenecarboxamide, N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-, monohydrochloride;M8-B;M8-B hydrochloride >=98% (HPLC);M8 B Hydrochloride,M-8-B Hydrochloride,M8B Hydrochloride;M8 B HCl
CAS:883976-12-3
MF:C22H25ClN2O3S
MW:432.9635
EINECS:
Product Categories:
Mol File:883976-12-3.mol
N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride Structure
N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride Chemical Properties
storage temp. 2-8°C
solubility H2O: soluble2mg/mL, clear (warmed)
form powder
color white to beige
Water Solubility H2O: 2mg/mL, clear (warmed)
InChI1S/C22H24N2O3S.ClH/c1-26-20-14-18(9-10-19(20)27-16-17-6-3-2-4-7-17)15-24(12-11-23)22(25)21-8-5-13-28-21;/h2-10,13-14H,11-12,15-16,23H2,1H3;1H
InChIKeyFMQJBHACRTZLME-UHFFFAOYSA-N
SMILES[s]1c(ccc1)C(=O)N(CCN)Cc2cc(c(cc2)OCc3ccccc3)OC.Cl
Safety Information
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride Usage And Synthesis
DescriptionM8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin , or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively). It displays no effect at other TRP channels. M8-B decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 KO mice.
UsesM8 B Hydrochloride is a channel blocker of cold receptor TRPM8.
in vivo

M8-B (6 mg/kg; i.v. or i.p.) decreases deep body body temperature (Tb) in rats and mouse[1].

Animal Model:Trpm8+/+ rats and mice[1]
Dosage:6 mg/kg
Administration:I.v. or i.p.
Result:Decreased deep body temperature (T(b)) in Trpm8+/+ rats and mice, but not in Trpm8/ mice.
IC 50TRPM8
storageStore at +4°C
References[1] M CAMILA ALMEIDA. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature.[J]. Journal of Neuroscience, 2012, 32 6: 2086-2099. DOI: 10.1523/jneurosci.5606-11.2012
N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride Preparation Products And Raw materials
Tag:N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride(883976-12-3) Related Product Information
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