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| | 7-HYDROXY-2,2-DIMETHYL-CHROMAN-4-ONE Basic information |
| Product Name: | 7-HYDROXY-2,2-DIMETHYL-CHROMAN-4-ONE | | Synonyms: | 2,2-Dimethyl-7-hydroxy-2,3-dihydro-4H-1-benzopyran-4-one;2,2-Dimethyl-7-hydroxychroman-4-one;2,3-Dihydro-7-hydroxy-2,2-dimethyl-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2,2-dimethyl-;7-hydroxy-2,2-dimethyl-4-chromanone;7-HYDROXY-2,2-DIMETHYL-2,3-DIHYDRO-4H-CHROMEN-4-ONE;7-HYDROXY-2,2-DIMETHYL-CHROMAN-4-ONE;7-Hydroxy-2,2-dimethyl-3,4-dihydro-2h-1-benzopyran-4-one | | CAS: | 17771-33-4 | | MF: | C11H12O3 | | MW: | 192.21 | | EINECS: | | | Product Categories: | | | Mol File: | 17771-33-4.mol |  |
| | 7-HYDROXY-2,2-DIMETHYL-CHROMAN-4-ONE Chemical Properties |
| Melting point | 172 °C(Solv: ethanol (64-17-5)) | | Boiling point | 354.3±42.0 °C(Predicted) | | density | 1.196±0.06 g/cm3(Predicted) | | pka | 7.75±0.40(Predicted) | | form | Solid | | color | Off-white to pink |
| HazardClass | IRRITANT | | HS Code | 2932990090 |
| | 7-HYDROXY-2,2-DIMETHYL-CHROMAN-4-ONE Usage And Synthesis |
| Uses | 7-Hydroxy-2,2-dimethyl-4-chromanone (compound 41) is an inhibitor of DC-SIGN (Dendritic Cell-Specific Intercellular Adhesion Molecule 3 grabbing non-integrin), with an IC50 of 4.66 mM[1]. DC-SIGN is the C-type lectin receptor presenting on the surface of both macrophages and dendritic cells[2]. | | References | [1] Wang J, et al. Negative regulation of Toll-like receptor signaling pathway. Microbes Infect. 2009 Mar;11(3):321-7. DOI:10.1016/j.micinf.2008.12.011
[2] Aaftaab Sethi, et al. Non-carbohydrate strategies to inhibit lectin proteins with special emphasis on galectins. Eur J Med Chem. 2021 Oct 15:222:113561. DOI:10.1016/j.ejmech.2021.113561 |
| | 7-HYDROXY-2,2-DIMETHYL-CHROMAN-4-ONE Preparation Products And Raw materials |
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