- RO8994
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- $48.00
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2026-07-27
- CAS:1309684-94-3
- Purity: 99.31%
- Supply Ability: 10g
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| Product Name: | RO8994 | | Synonyms: | RO8994;(2'S,3R,4'S,5'R)-N-[4-(Aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide;CS-2264;RO8994;RO-8994;RO 8994;RO-8994;RO 8994;Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-, (2'S,3R,4'S,5'R)-;E2 conjugating enzyme,MDM-2/p53,Ubiquitin conjugating enzyme,Ubiquitin activating enzyme,E3 ligating enzyme,RO8994,inhibit,Inhibitor,RO 8994,RO-8994,E1/E2/E3 Enzyme,E1 activating enzyme,Ubiquitin ligase;(2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'- | | CAS: | 1309684-94-3 | | MF: | C31H31Cl2FN4O4 | | MW: | 613.51 | | EINECS: | | | Product Categories: | | | Mol File: | 1309684-94-3.mol |  |
| | RO8994 Chemical Properties |
| Boiling point | 753.5±60.0 °C(Predicted) | | density | 1.41±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF:12.5(Max Conc. mg/mL);20.4(Max Conc. mM)
DMSO:14.0(Max Conc. mg/mL);22.8(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);8.1(Max Conc. mM) | | form | A crystalline solid | | pka | 12.00±0.70(Predicted) | | color | White to off-white | | InChIKey | MURAVORBGFDSMA-ISKXDESKSA-N | | SMILES | N1C2=C(C=CC(Cl)=C2)[C@@]2([C@@H](C3=CC=CC(Cl)=C3F)[C@H](C(NC3=CC=C(C(N)=O)C=C3OC)=O)N[C@H]2CC(C)(C)C)C1=O |
| | RO8994 Usage And Synthesis |
| Description | RO8994 is an inhibitor of the protein-protein interaction between MDM2 and the tumor suppressor p53 in a homogeneous time-resolved fluorescence (HTRF) binding assay (IC50 = 5 nM). It inhibits the proliferation of SJSA-1, RKO, and HCT116 cells with an average IC50 value of 20 nM and increases apoptosis in SJSA-1 cells in a concentration-dependent manner. RO8994 reduces tumor growth and induces tumor regression in an SJSA-1 osteosarcoma mouse xenograft model when administered at doses of 1.56 and 6.25 mg/kg, respectively. | | Uses | RO 8994 is a potent and selective spiroindolinone MDM2 inhibitor, and potential useful for cancer therapy. | | References | [1] ZHUMING ZHANG . Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy[J]. Bioorganic & Medicinal Chemistry, 2014, 22 15: Pages 4001-4009. DOI: 10.1016/j.bmc.2014.05.072 |
| | RO8994 Preparation Products And Raw materials |
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