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| | 2-(Azido-PEG2-amido)-1,3-propandiol Basic information |
| | 2-(Azido-PEG2-amido)-1,3-propandiol Chemical Properties |
| | 2-(Azido-PEG2-amido)-1,3-propandiol Usage And Synthesis |
| Description | 2-(Azido-PEG2-amido)-1,3-propandiol is a branched PEG derivtive containing terminal azide moieties and two primary alcohol groups. The azide group can participate in copper-catalyzed Click Chemistry reactions with alkyne, DBCO and BCN moieties. The hydroxyl groups can react to further derivatize the compound. PEG linker increases solubility of compounds in aqueous media. | | Uses | 2-(Azido-PEG2-amido)-13-propandiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 2-(Azido-PEG2-amido)-1,3-propandiol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | 2-(Azido-PEG2-amido)-1,3-propandiol Preparation Products And Raw materials |
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