| Company Name: |
Twochem Co.Ltd |
| Tel: |
021-021-58111628 15800915896 |
| Email: |
sales@twochem.com |
- PZM-21
-
- $7.00
-
2026-06-24
- CAS:1997387-43-5
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000KGS
- PZM21
-
- $39.00
-
2026-06-02
- CAS:1997387-43-5
- Purity: 99.93%
- Supply Ability: 10g
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| | 1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea Basic information |
| | 1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea Chemical Properties |
| Boiling point | 583.8±50.0 °C(Predicted) | | density | 1.169±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:100.0(Max Conc. mg/mL);276.63(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);27.7(Max Conc. mM) | | form | A crystalline solid | | pka | 10.06±0.15(Predicted) | | color | White to off-white |
| | 1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea Usage And Synthesis |
| Uses | PZM21 is a potent Gi activator with exceptional selectivity for μOR and minimal β-arrestin-2 recruitment. PZM21 is an experimental opioid analgesic drug that is being researched for the treatment of pain. It is a functionally selective μ-opioid receptor agonist which produces μ-opioid receptor mediated G protein signaling, with potency and efficacy similar to morphine, but with less β-arrestin 2 recruitment. In tests on mice, PZM21 was slightly less potent than morphine or TRV130 as an analgesic, but also had significantly reduced adverse effects, with less constipation than morphine, and very little respiratory depression, even at high doses. | | in vivo | PZM21 is a potent Gi activator with exceptional selectivity for μOR and minimal β-arrestin-2 recruitment. PZM21 is efficacious for the affective component of analgesia versus the reflexive component and is devoid of respiratory depression in mice at equi-analgesic doses. PZM21 displays dose-dependent analgesia in a mouse hotplate assay, with a per cent maximal possible effect (% MPE) of 87% reached 15 min after administration of the highest dose of drug tested [1].PZM21 has a long-lasting analgesic effect on CNS mediated-pain responses, but does not cause respiratory depression and constipation, two key side effects of opioid agonists[2]. | | IC 50 | μ Opioid Receptor/MOR | | storage | Store at -20°C |
| | 1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea Preparation Products And Raw materials |
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