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2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER

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CAS:660867-80-1
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Products Intro: Product Name:2-Methylpyridine-4-boronic acid pinacol ester
CAS:660867-80-1
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CAS:660867-80-1
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Products Intro: Product Name:2-Methylpyridine-4-boronic Acid Pinacol Ester
CAS:660867-80-1
Purity:>=98% Package:1g;5g;10g;25g;100g;500g

2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER manufacturers
2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER Basic information
Product Name:2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER
Synonyms:2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER;2-METHYL-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE;2-Picoline-4-boronic acid pinacol ester;2-Picoline-4-boronic acid pinacolate;2-Methyl-4-pyridineboronic acid pinacol ester;2-Methylpyridine-4-boronic acid pinacol;2-Methylpyridine-4-boronic acid pinacol ester, 95%, May contain up to 3% water;2-aMino-4-pyridine boronic ester
CAS:660867-80-1
MF:C12H18BNO2
MW:219.09
EINECS:
Product Categories:Organic boronic acid;Boronic ester;Organoborons;Pyridine
Mol File:660867-80-1.mol
2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER Structure
2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER Chemical Properties
Melting point 66-71°C
Boiling point 315.9±30.0 °C(Predicted)
density 1.02
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility soluble in Methanol
form powder to crystal
pka5.11±0.10(Predicted)
color White to Almost white
InChI1S/C12H18BNO2/c1-9-8-10(6-7-14-9)13-15-11(2,3)12(4,5)16-13/h6-8H,1-5H3
InChIKeyMBTULFIFECUURA-UHFFFAOYSA-N
SMILESCc1cc(ccn1)B2OC(C)(C)C(C)(C)O2
Safety Information
Hazard Codes Xi
Risk Statements 37/38-41
Safety Statements 26-39
WGK Germany WGK 3
HS Code 2933399990
Storage Class11 - Combustible Solids
MSDS Information
2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER Usage And Synthesis
Synthesis
4-Bromo-2-methylpyridine

22282-99-1

Bis(pinacolato)diboron

73183-34-3

2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER

660867-80-1

The general procedure for the synthesis of 2-methyl-4-pyridylboronic acid pinacol ester from 4-bromo-2-methylpyridine (0.500 g, 2.906 mmol) and pinacol ester of bis(diphenylphosphine) (0.812 g, 3.997 mmol) is as follows: in an inert atmosphere, 4-bromo-2-methylpyridine, pinacol ester of bis(boronic acid), potassium acetate (0.854 g, 8.720 mmol) and [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride (0.021 g, 0.029 mmol) were dissolved in degassed 1,4-dioxane (5 mL) in a 50 mL sealed tube. The reaction mixture was stirred at 80 °C for 4 hours. Upon completion of the reaction, the solvent was removed by rotary evaporation and the crude product was purified by silica gel column chromatography (eluent: ethyl acetate/ether = 30:70) to afford 2-methyl-4-pyridinylboronic acid pinacol ester (0.250 g, 39% yield) as an off-white solid. m/z 220.1 [M + H]+ was shown by LCMS analysis.

References[1] Patent: WO2014/111871, 2014, A1. Location in patent: Page/Page column 199
[2] Patent: WO2004/14913, 2004, A2. Location in patent: Page 82
[3] Patent: US2011/190269, 2011, A1. Location in patent: Page/Page column 36
[4] Patent: WO2011/92272, 2011, A1. Location in patent: Page/Page column 73
[5] Patent: WO2011/119518, 2011, A1. Location in patent: Page/Page column 47-48
Tag:2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER(660867-80-1) Related Product Information
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