3-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid hydrazide manufacturers
- Azido-PEG4-hydrazide
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2025-06-07
- CAS:2170240-96-5
- Min. Order: 250mg
- Purity: >98.00%
- Supply Ability: 250mg
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| | 3-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid hydrazide Basic information |
| | 3-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid hydrazide Chemical Properties |
| storage temp. | -20°C, protect from light | | solubility | DMSO : 100 mg/mL (327.51 mM) | | form | Liquid | | color | Colorless to light yellow | | Appearance | white-yellow solid |
| | 3-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid hydrazide Usage And Synthesis |
| Description | Azido-PEG4-hydrazide HCl salt is a PEG linker containing an azide group and a hydrazide group. The hydrophilic PEG spacer increases solubility of a compound in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydrazide group can react with an aldehyde to form a semi-permanent hydrozone bond. | | Uses | Azido-PEG4-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | 3-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid hydrazide Preparation Products And Raw materials |
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