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| | m-PEG8-succinimidyl carbonate Basic information |
| Product Name: | m-PEG8-succinimidyl carbonate | | Synonyms: | m-PEG8-succinimidyl carbonate;2,5,8,11,14,17,20,23,26-Nonaoxaheptacosanoic acid, 2,5-dioxo-1-pyrrolidinyl ester | | CAS: | 1372860-04-2 | | MF: | C22H39NO13 | | MW: | 525.54 | | EINECS: | | | Product Categories: | | | Mol File: | 1372860-04-2.mol |  |
| | m-PEG8-succinimidyl carbonate Chemical Properties |
| Boiling point | 569.1±60.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF |
| | m-PEG8-succinimidyl carbonate Usage And Synthesis |
| Description | m-PEG8-succinimidyl carbonate is a PEG linker containing a succinimidyl carbonate group. Succinimidyl carbonate group is a good leaving group and commonly reacts with amine nucleophiles. The hydrophilic PEG linker increases the water solubility properties of the compound. | | Uses | m-PEG8-succinimidyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | m-PEG8-succinimidyl carbonate Preparation Products And Raw materials |
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