N-(Amino-PEG1)-N-bis(PEG2-propargyl) HCl salt manufacturers
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| | N-(Amino-PEG1)-N-bis(PEG2-propargyl) HCl salt Basic information |
| | N-(Amino-PEG1)-N-bis(PEG2-propargyl) HCl salt Chemical Properties |
| Boiling point | 443.9±40.0 °C(Predicted) | | density | 1.061±0.06 g/cm3(Predicted) | | solubility | Soluble in Water, DMSO | | pka | 8.83±0.10(Predicted) |
| | N-(Amino-PEG1)-N-bis(PEG2-propargyl) HCl salt Usage And Synthesis |
| Description | N-(Amino-PEG1)-N-bis(PEG2-propargyl) HCl salt is a crosslinker consisting of an amino group with two propargyl groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The propargyl groups can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. | | Uses | N-(Amino-PEG1)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Amino-PEG1)-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
| | N-(Amino-PEG1)-N-bis(PEG2-propargyl) HCl salt Preparation Products And Raw materials |
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