N-Boc-N-bis(PEG2-propargyl) manufacturers
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| | N-Boc-N-bis(PEG2-propargyl) Basic information |
| | N-Boc-N-bis(PEG2-propargyl) Chemical Properties |
| Boiling point | 442.8±45.0 °C(Predicted) | | density | 1.068±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | form | Liquid | | pka | -1.61±0.70(Predicted) | | color | Colorless to light yellow |
| | N-Boc-N-bis(PEG2-propargyl) Usage And Synthesis |
| Description | N-Boc-N-bis(PEG2-propargyl) enables Click Chemistry reactions with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The Boc-protected amine can be deprotected under acidic conditions. | | Uses | N-Boc-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Boc-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-Boc-N-bis(PEG2-propargyl) Preparation Products And Raw materials |
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