N-Mal-N-bis(PEG4-NHS ester) manufacturers
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| | N-Mal-N-bis(PEG4-NHS ester) Basic information |
| Product Name: | N-Mal-N-bis(PEG4-NHS ester) | | Synonyms: | N-Mal-N-bis(PEG4-NHS ester);4,7,10,13,19,22,25,28-Octaoxa-16-azahentriacontanedioic acid, 16-[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]-, 1,31-bis(2,5-dioxo-1-pyrrolidinyl) ester;Bis(2,5-dioxopyrrolidin-1-yl) 16-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl)-4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontane-1,31-dioate;bis(2,5-dioxopyrrolidin-1-yl) 16-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl)-4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontanedioate | | CAS: | 2112738-60-8 | | MF: | C37H54N4O19 | | MW: | 858.84 | | EINECS: | | | Product Categories: | | | Mol File: | 2112738-60-8.mol |  |
| | N-Mal-N-bis(PEG4-NHS ester) Chemical Properties |
| Boiling point | 892.3±75.0 °C(Predicted) | | density | 1.37±0.1 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF | | pka | -0.93±0.70(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | N-Mal-N-bis(PEG4-NHS ester) Usage And Synthesis |
| Description | N-Mal-N-bis(PEG4-NHS ester) is a branched maleimide linker with two terminal NHS esters. NHS esters is used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule. | | Uses | N-Mal-N-bis(PEG4-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-Mal-N-bis(PEG4-NHS ester) Preparation Products And Raw materials |
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