- 6-Nitroindazole
-
-
2026-02-02
- CAS:7597-18-4
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 2000tons
- 6-Nitroindazole
-
-
2025-12-24
- CAS:7597-18-4
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 1000 tons
- 6-Nitro-1H-indazole
-
-
2025-12-15
- CAS:7597-18-4
- Min. Order: 1kg
- Purity: ≥98% by HPLC
- Supply Ability: 100kg/month
|
| | 6-Nitroindazole Basic information |
| | 6-Nitroindazole Chemical Properties |
| Melting point | 180-182 °C (lit.) | | Boiling point | 290.19°C (rough estimate) | | density | 1.4141 (rough estimate) | | refractive index | 1.5500 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | very faint turbidity in hot Methanol | | pka | 11.08±0.40(Predicted) | | form | Powder | | color | Light Yellow | | BRN | 7812 | | InChI | InChI=1S/C7H5N3O2/c11-10(12)6-2-1-5-4-8-9-7(5)3-6/h1-4H,(H,8,9) | | InChIKey | ORZRMRUXSPNQQL-UHFFFAOYSA-N | | SMILES | N1C2=C(C=CC([N+]([O-])=O)=C2)C=N1 | | CAS DataBase Reference | 7597-18-4(CAS DataBase Reference) | | NIST Chemistry Reference | 6-Nitroindazole(7597-18-4) | | EPA Substance Registry System | 1H-Indazole, 6-nitro- (7597-18-4) |
| Hazard Codes | Xn,Xi | | Risk Statements | 20/21/22-36/37/38-40-68-36 | | Safety Statements | 26-27-36/37/39 | | WGK Germany | 3 | | RTECS | NK7962100 | | TSCA | TSCA listed | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 6-Nitroindazole Usage And Synthesis |
| Description | 6-Nitroindazole is a competitive and reversible Monoamine oxidase(MAO)inhibitor. It can inhibit MAO-A and MAO-B (IC50= 2.5 μM). Monoamine oxidase (MAO) B is a mitochondrial enzyme selectively involved in the oxidative activation of 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to toxic pyridinium cations producing Parkinsonism in animal models. In addition, it is an nNOS inhibitor, which has neuroprotective effects[1].
| | Chemical Properties | yellow powder | | Uses | Anticonvulsant. | | Synthesis | 6-Nitroindazole is prepared by (2-methyl-5-nitrophenyl)azo phenyl sulfide and 1,8-diazabicyclo[5.4.0]undec-7-ene in the presence of concentrated acetonitrile. | | References | [1] HERRAIZTOMAS GuillénHugo AránVicente J. Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO).[J]. Free Radical Research, 2009: 975-984. DOI:10.1080/10715760903159170. |
| | 6-Nitroindazole Preparation Products And Raw materials |
|