- mPEG9-OH
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2026-01-28
- CAS:6048-68-6
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 500kg
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| | Nonaethylene Glycol Monomethyl Ether Basic information |
| | Nonaethylene Glycol Monomethyl Ether Chemical Properties |
| Melting point | 14 °C | | Boiling point | 170 °C(Press: 0.01 Torr) | | density | 1.10 | | refractive index | 1.4570 to 1.4620 | | storage temp. | Storage temp. 2-8°C | | pka | 14.36±0.10(Predicted) | | form | clear liquid | | color | Colorless to Light yellow to Light orange | | InChI | InChI=1S/C19H40O10/c1-21-4-5-23-8-9-25-12-13-27-16-17-29-19-18-28-15-14-26-11-10-24-7-6-22-3-2-20/h20H,2-19H2,1H3 | | InChIKey | VVHAVLIDQNWEKF-UHFFFAOYSA-N | | SMILES | C(O)COCCOCCOCCOCCOCCOCCOCCOCCOC |
| | Nonaethylene Glycol Monomethyl Ether Usage And Synthesis |
| Description | m-PEG9-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | Nonaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | Definition | ChEBI: Nonaethylene glycol monomethyl ether is nonaethylene glycol in which one of the hydroxy groups is substituted by methoxy. It is functionally related to a nonaethylene glycol. | | in vitro |
Nonaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used to synthesize PROTACs.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase, and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
| | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Nonaethylene Glycol Monomethyl Ether Preparation Products And Raw materials |
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