2-(4-Chlorophenyl)thiazole-5-carbaldehyde

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2-(4-Chlorophenyl)thiazole-5-carbaldehyde Basic information
Product Name:2-(4-Chlorophenyl)thiazole-5-carbaldehyde
Synonyms:2-(4-CHLOROPHENYL)THIAZOLE-5-CARBALDEHYDE;2-(4-hydroxyphenyl)thiazole-5-carbaldehyde;2-(4-chlorophenyl)-1,3-thiazole-5-carbaldehyde;5-Thiazolecarboxaldehyde, 2-(4-chlorophenyl)-
CAS:721920-84-9
MF:C10H6ClNOS
MW:223.68
EINECS:200-258-5
Product Categories:API intermediates
Mol File:721920-84-9.mol
2-(4-Chlorophenyl)thiazole-5-carbaldehyde Structure
2-(4-Chlorophenyl)thiazole-5-carbaldehyde Chemical Properties
Boiling point 377.6±48.0 °C(Predicted)
density 1.388±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka0.14±0.10(Predicted)
Safety Information
Risk Statements 43
Safety Statements 36/37
MSDS Information
2-(4-Chlorophenyl)thiazole-5-carbaldehyde Usage And Synthesis
Synthesis
2-CHLOROMALONALDEHYDE

36437-19-1

4-Chlorothiobenzamide

2521-24-6

2-(4-Chlorophenyl)thiazole-5-carbaldehyde

721920-84-9

Step 1. Synthesis of 2-(4-chlorophenyl)-1,3-thiazole-5-carbaldehyde. 4-Chlorobenzamide (5 g, 29.1 mmol), magnesium bicarbonate pentahydrate (7.06 g, 14.55 mmol) and 2-chloromalonaldehyde (4.65 g, 43.65 mmol) were added to a flask and the reaction was stirred for 3 hr at 60 °C under nitrogen protection. Upon completion of the reaction, the reaction mixture was allowed to pass through a silica plug for rapid column chromatography and washed with ethyl acetate. The solvent was removed by concentration under reduced pressure to afford the target product 2-(4-chlorophenyl)-1,3-thiazole-5-carbaldehyde (6 g, 92% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 10.06 (s, 1H), 8.43 (s, 1H), 7.99-7.96 (m, 2H), 7.49-7.46 (m, 2H).

References[1] Patent: WO2004/58761, 2004, A1. Location in patent: Page 37-38
[2] Patent: WO2011/12862, 2011, A1. Location in patent: Page/Page column 102; 109
2-(4-Chlorophenyl)thiazole-5-carbaldehyde Preparation Products And Raw materials
Raw materials2-CHLOROMALONALDEHYDE-->4-Chlorothiobenzamide-->tetra[carbonato(2-)]dihydroxypentamagnesium
Tag:2-(4-Chlorophenyl)thiazole-5-carbaldehyde(721920-84-9) Related Product Information
Fosthiazate Chlorodimethylphenylsilane Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Benzothiazole Triphenylmethyl Chloride ETHYL 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE 1-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-5-YL]-3-(DIMETHYLAMINO)-2-PROPEN-1-ONE 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID ETHYL 2-(4-CHLOROPHENYL)-4-HYDROXY-1,3-THIAZOLE-5-CARBOXYLATE METHYL 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE ETHYL 2-(2,4-DICHLOROPHENYL)-4-HYDROXYTHIAZOLE-5-CARBOXYLATE 2-(4-Chlorophenyl)thiazole-5-carbaldehyde [2-(4-CHLOROPHENYL)-1,3-THIAZOL-5-YL](PHENYL)METHANONE [1,1'-BIPHENYL]-4-YL[2-(4-CHLOROPHENYL)-1,3-THIAZOL-5-YL]METHANONE 3-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-5-YL]-3-OXOPROPANAL O-(2-[3-(TRIFLUOROMETHYL)PHENOXY]ETHYL)OXIME (4-BROMOPHENYL)[2-(4-CHLOROPHENYL)-1,3-THIAZOL-5-YL]METHANONE [2-(4-CHLOROPHENYL)-1,3-THIAZOL-5-YL](3,4-DICHLOROPHENYL)METHANONE 2-(4-CHLOROPHENYL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBOXAMIDE