4-methyl-7-[4-nitro-2-(trifluoromethyl)phenoxy]chromen-2-one

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Company Name:	Shanghai Hongye Biotechnology Co. Ltd
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Company Name:	ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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4-methyl-7-[4-nitro-2-(trifluoromethyl)phenoxy]chromen-2-one Basic information

Product Name:	4-methyl-7-[4-nitro-2-(trifluoromethyl)phenoxy]chromen-2-one
Synonyms:	4-methyl-7-[4-nitro-2-(trifluoromethyl)phenoxy]chromen-2-one;4-Methyl-7-(4-nitro-2-(trifluoromethyl)phenoxy)-2H-chromen-2-one;2H-1-Benzopyran-2-one, 4-methyl-7-[4-nitro-2-(trifluoromethyl)phenoxy]-;4-methyl-7-[4-nitro-2-(trifluoromethyl)phenoxy]-2H-1-benzopyran-2-one
CAS:	433254-36-5
MF:	C17H10F3NO5
MW:	365.26
EINECS:
Product Categories:
Mol File:	433254-36-5.mol

4-methyl-7-[4-nitro-2-(trifluoromethyl)phenoxy]chromen-2-one Chemical Properties

Boiling point	437.5±45.0 °C(Predicted)
density	1.455±0.06 g/cm3(Predicted)
solubility	Chloroform: 30 mg/ml; DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml; DMSO: 5 mg/ml
form	A crystalline solid

Safety Information

MSDS Information

4-methyl-7-[4-nitro-2-(trifluoromethyl)phenoxy]chromen-2-one Usage And Synthesis

Description	4-Methyl-7-(4-nitro-2-(trifluoromethyl)phenoxy)-2H-chromen-2-one is a turn-on fluorescent probe for the detection of hydrogen sulfide (H₂S). It can be excited at 348 nm in DMSO and fluorescence intensity increases in the presence of bisulfide (HS^-). 4-Methyl-7-(4-nitro-2-(trifluoromethyl)phenoxy)-2H-chromen-2-one is selective for HS^- over cysteine, AcO^-, F^-, H₂PO₄^-, Cl^-, Br^-, and I^- and is not cytotoxic up to a concentration of 150 μg/ml.
Uses	H2S Fluorescent probe 1 (Compound 2) is a fluorescent probe that detects hydrogen sulfide (H2S) with almost no cytotoxicity. Upon the addition of increasing amounts of HS- to DMSO solution of H2S Fluorescent probe 1, a new absorption peak appears gradually at 485 nm. H2S Fluorescent probe 1, the fluorescence intensity notes at 434 nm increasing rapidly by titration of HS-[1].
References	[1] Chen Y, et al. The synthesis, crystal, hydrogen sulfide detection and cell assement of novel chemsensors based on coumarin derivatives. Sci Rep. 2018 Nov 1;8(1):16159. DOI:10.1038/s41598-018-34331-9

4-methyl-7-[4-nitro-2-(trifluoromethyl)phenoxy]chromen-2-one Preparation Products And Raw materials

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