3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)

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3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) Basic information
Product Name:3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)
Synonyms:3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one);-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one);2H-1-Benzopyran-2-one, 3,3'-[(2-chlorophenyl)methylene]bis[4-hydroxy-;3,3′-[(2-chlorophenyl)methylene]bis[4-hydroxy-2H-1-benzopyran-2-one;3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)
CAS:4322-58-1
MF:C25H15ClO6
MW:446.84
EINECS:
Product Categories:
Mol File:4322-58-1.mol
3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) Structure
3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) Chemical Properties
Melting point 198-199 °C
Boiling point 703.3±60.0 °C(Predicted)
density 1.575±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.14 mg/ml
form A crystalline solid
pka4.20±1.00(Predicted)
Safety Information
MSDS Information
3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) Usage And Synthesis
Description3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) is a non-nucleotide inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; Ki = 50 μM).1,2 It also inhibits urease (IC50 = 84.53 μM for the Jack bean enzyme).3
UsesUrease-IN-17 (9) is a urease inhibitor, with an IC50 of 84 μM[1].
References1. Choudhary, M.I., Fatima, N., Khan, K.M., et al. New biscoumarin derivatives-cytotoxicity and enzyme inhibitory activities Bioorg. Med. Chem. 14(23),8066-8072(2006).
2. Onyedibe, K.I., Wang, M., and Sintim, H.O. ENPP1, an old enzyme with new functions, and small molecule inhibitors - A STING in the tale of ENPP1 Molecules 24(22),E4192(2019).
3. Khan, K.M., Iqbal, S., Lodhi, M.A., et al. Biscoumarin: New class of urease inhibitors; economical synthesis and activity Bioorg. Med. Chem. 12(8),1963-1968(2004).
3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) Preparation Products And Raw materials
Tag:3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)(4322-58-1) Related Product Information
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