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| | 4-Chloro-4'-hydroxybenzophenone Basic information |
| | 4-Chloro-4'-hydroxybenzophenone Chemical Properties |
| Melting point | 177-181 °C | | Boiling point | 257 °C (13 mmHg) | | density | 1.2082 (rough estimate) | | refractive index | 1.5434 (estimate) | | Fp | 100 °C | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) | | pka | 7.68±0.15(Predicted) | | form | solid | | color | Pale Beige to Light Brown | | BRN | 2049956 | | Major Application | pharmaceutical small molecule | | InChI | InChI=1S/C13H9ClO2/c14-11-5-1-9(2-6-11)13(16)10-3-7-12(15)8-4-10/h1-8,15H | | InChIKey | RUETVLNXAGWCDS-UHFFFAOYSA-N | | SMILES | C(C1=CC=C(Cl)C=C1)(C1=CC=C(O)C=C1)=O | | CAS DataBase Reference | 42019-78-3(CAS DataBase Reference) | | NIST Chemistry Reference | Methanone, (4-chlorophenyl)(4-hydroxyphenyl)-(42019-78-3) |
| | 4-Chloro-4'-hydroxybenzophenone Usage And Synthesis |
| Chemical Properties | light grey to beige-brown powder | | Uses | 4-Chloro-4’-hydroxybenzophenone (Fenofibrate EP Impurity A; Fenofibrate USP Related Compound A) the impurity of Fenofibric acid (42017-89-0), the active metabolite of fenofibrate which increases Apolipoprotein A-I–Mediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptor–dependent manner. | | Preparation | Preparation by Fries rearrangement of phenyl p-chloro-benzoate,
in the presence of aluminium chloride, without solvent, at 160° for 5 min, between 120° and 160° (good yield) or at 130° for 1 h, then at 160° for 1 h (10%) or in refluxing chlorobenzene for 10 h (52%);
in the presence of trifluoromethanesulfonic acid at 45–55° (94%). |
| | 4-Chloro-4'-hydroxybenzophenone Preparation Products And Raw materials |
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