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| | Methyl 2-bromomethyl-6-chloro-benzoate Basic information |
| Product Name: | Methyl 2-bromomethyl-6-chloro-benzoate | | Synonyms: | METHYL 2-BROMOMETHYL-6-CHLORO-BENZOATE Benzoic acid, 2-(bromomethyl)-6-chloro-, methyl ester;Benzoic acid, 2-(bromomethyl)-6-chloro-, methyl ester;Methyl 2-bromomethyl-6-chloro-benzoate | | CAS: | 482578-63-2 | | MF: | C9H8BrClO2 | | MW: | 263.52 | | EINECS: | | | Product Categories: | | | Mol File: | 482578-63-2.mol |  |
| | Methyl 2-bromomethyl-6-chloro-benzoate Chemical Properties |
| | Methyl 2-bromomethyl-6-chloro-benzoate Usage And Synthesis |
| Synthesis | Methyl 2-chloro-6-methylbenzoate (1 g, 5.4 mmol) was used as starting material and dissolved in carbon tetrachloride (50 mL). Subsequently, N-bromosuccinimide (1 g, 5.9 mmol) and benzoyl peroxide (0.131 g, 0.5 mmol) were sequentially added to this solution. The reaction mixture was stirred continuously at 80 °C for 10 hours. After completion of the reaction, the mixture was filtered through diatomaceous earth to remove insoluble impurities. The filtrate was concentrated under reduced pressure to afford the target product methyl 2-(bromomethyl)-6-chlorobenzoate (1.2 g). The structure of the product was confirmed by LC-MS with a calculated exact mass of 261.94 and a measured value of m/z 263.0 [M + H]+. | | References | [1] Patent: WO2006/77414, 2006, A1. Location in patent: Page/Page column 150
[2] Patent: US2010/249095, 2010, A1. Location in patent: Page/Page column 91
[3] Patent: US2007/32475, 2007, A1. Location in patent: Page/Page column 32
[4] Patent: EP1408033, 2004, A1. Location in patent: Page 115
[5] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 1, p. 360 - 365 |
| | Methyl 2-bromomethyl-6-chloro-benzoate Preparation Products And Raw materials |
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