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| Product Name: | O4I1 | | Synonyms: | 2-(4-[(4-METHOXYBENZYL)OXY]PHENYL)ACETONITRILE;O411;O4I1;4-(4-METHOXYBENZYLOXY)PHENYLACETONITRILE;4-[(4-Methoxyphenyl)methoxy]benzeneacetonitrile;2-[4-[(4-methoxyphenyl)methoxy]phenyl]acetonitrile;O4I1, >98%;OSI 1 | | CAS: | 175135-47-4 | | MF: | C16H15NO2 | | MW: | 253.3 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 175135-47-4.mol |  |
| Boiling point | 424.5±30.0 °C(Predicted) | | density | 1.129±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml; Ethanol: slightly | | form | A crystalline solid | | color | Light yellow to yellow |
| Description | O4I1 is an inducer of Oct3/4 expression and translation in diverse human cell lines (increases Oct3/4 mRNA in HEK293 cells by 2.5- and 4-fold at 10 and 20 μM, respectively). It also induces Oct3/4 expression and translation in terminally differentiated human fibroblasts. Through this action, O4I1 promotes the expression of pluripotency-associated genes in human neonatal foreskin fibroblasts. | | Uses | O4I1 is a potent Oct3/4 inducer. It promotes expression and stabilization of Oct3/4, and also enhanced its transcriptional activity in human somatic cells, making it useful in regenerative medicine. | | References | [1] XINLAI CHENG. Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers[J]. Journal of Medicinal Chemistry, 2015, 58 12: 4976-4983. DOI: 10.1021/acs.jmedchem.5b00144 |
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