Protein degrader 1 (TFA) manufacturers
- (S,R,S)-AHPC TFA
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- $30.00
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2026-07-14
- CAS:1631137-51-3
- Purity: 97.99%
- Supply Ability: 10g
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| | Protein degrader 1 (TFA) Basic information |
| Product Name: | Protein degrader 1 (TFA) | | Synonyms: | Protein degrader 1 (TFA);E3 ligase Ligand 6;VHL ligand 1 (TFA);(S,R,S)-AHPC TFA;VH032-NH2 TFA;(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2,2,2-trifluoroacetate;S)-AHPC TFA;VH032-NH2,Inhibitor,inhibit,E3 ligase-recruiting Moiety,Ligands for E3 Ligase,(S,R,S)-AHPC,(S,R,S)AHPC TFA,VHL ligand 1,VHL ligand1,VHL ligand-1,(S,R,S) AHPC TFA | | CAS: | 1631137-51-3 | | MF: | C24H31F3N4O5S | | MW: | 544.59 | | EINECS: | | | Product Categories: | | | Mol File: | 1631137-51-3.mol |  |
| | Protein degrader 1 (TFA) Chemical Properties |
| | Protein degrader 1 (TFA) Usage And Synthesis |
| Description | VHL-7526, also known as Protein degrader 1, is a protein degrader and is a small molecule ligand for VHL | | Uses | (S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1]. | | IC 50 | VHL | | References | [1] Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7. DOI:10.1021/acschembio.5b00442 |
| | Protein degrader 1 (TFA) Preparation Products And Raw materials |
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